毫米波辐照大鼠引起脑电变化及应激反应  

EEG Changes and Stress Reactions in Rat Induced by Millimeter Wave

作　　者：谢涛嵘[1] 裴剑[1] 李芬[1] 黄欣[1] 陈树德[1] 乔登江[1] 

机构地区：[1]华东师范大学物理系,精密光谱科学与技术国家重点实验室,上海200241

出　　处：《生物医学工程学杂志》2011年第1期40-44,共5页Journal of Biomedical Engineering

基　　金：长江学者和创新团队发展计划资助项目;上海市重点学科建设资助项目(B408)

摘　　要：为了定量分析35 GHz毫米波辐照大鼠引起的应激反应过程及其判断根据,本文测量辐照引起的大鼠脑电(EEG)变化,并使用小波分析及脑电能量相对变化率方法定量分析,得到毫米波辐照下,大鼠会依次经历平静期、警戒期、相持期、衰竭期。根据应激各阶段的温升、皮肤损伤、血液生化指标变化,得到毫米波引起大鼠各个应激阶段的判断根据是:受照部位表皮温度达到热痛阈值时大鼠从平静期进入警戒期;当皮肤损伤较为严重时,其应激反应敏感度下降,大鼠从警戒期进入相持期,同时其内脏器官出现损伤;继续辐照使得大鼠内部重要器官损伤加重而进入衰竭期,直到衰竭而死亡。The present paper is aimed to study the processes of stress reaction and their judgment bases in rat induced by 35GHz millimeter wave quantitatively.The relative change in the average energy of each EEG frequency band decomposed by wavelet analysis was calculated for extracting the stress indicator for the purpose.The rat would experience quiet period,guarding period,deadlock period and prostrating period in sequence.The judgment bases of different stress periods in rat induced by millimeter wave were obtained by analyzing the skin temperature,skin injury and changes of blood biochemical indexes during each stress period.The stress period changed from quiet period to guarding period when the skin temperature of irradiated area reached the thermal pain threshold.It was from guarding period to deadlock period when the skin had gotten serious injury.Then the rat reaction sensitivity decreased,and injury of its visceral organs occurred.The rat got to prostrating period when the sustained irradiation caused the rat＇s visceral organs to get more serious injury.The further sustained irradiation finally induced death of the rat.

关 键 词：热效应 节律 小波分析 皮肤切片 

分 类 号：Q684[生物学—生物物理学]