可降解多元氨基酸共聚物/磷酸钙复合材料椎间融合器植入山羊颈椎即刻稳定性的生物力学评价  

Biomechanical Evaluation of Immediate Stability of Biodegradable Multi-amino Acid Copolymer/Tri-calcium Phosphate Composite Interbody Cages in a Goat Cervical Spine Model

作　　者：周春光[1] 宋跃明[1] 屠重棋[1] 段宏[1] 裴福兴[1] 严永刚[2] 李鸿[2] 

机构地区：[1]四川大学华西医院骨科,成都610041 [2]四川大学物理学院,成都610064

出　　处：《生物医学工程学杂志》2011年第1期63-66,共4页Journal of Biomedical Engineering

基　　金：国家科技支撑计划项目资助(2007BAE13B04)

摘　　要：设计制备可降解多元氨基酸共聚物/磷酸钙复合材料椎间融合器(MAACP/TCP Cage),探讨其对山羊颈椎C3-4融合术后的即刻稳定作用。首先对正常山羊颈椎进行测试,之后将27个标本随机分为3组,这样实验共有4组:A组:MAACP/TCP Cage组(n=9);B组:钛合金Cage组(n=9);C组:三面皮质髂骨组(n=9);D组:正常对照组(n=27)。切除颈3/4椎间盘后植入以上内植物,采用非破坏刚度法进行前屈、后伸、侧屈和旋转的生物力学测定,由此计算出各组活动范围(ROM)及相对刚度,并行比较。与正常对照组相比,MAACP/TCP Cage植入后,颈3-4节段屈曲和左、右侧屈的ROM下降,相对刚度提高(P<0.05);与髂骨组相比,MAACP/TCP Cage植入后,颈3-4节段后伸、屈曲和左、右侧屈的ROM低于髂骨组,相对刚度高于髂骨组(P<0.05);与钛合金Cage组相比,MAACP/TCP Cage植入后,颈3-4节段屈曲、后伸和左、右侧屈的ROM及相对刚度无明显差别(P>0.05),而旋转的ROM高于钛合金Cage组,相对刚度低于钛合金Cage组(P<0.05)。结论:MAACP/TCP Cage可为山羊颈椎椎间融合提供足够的初始生物力学稳定性。A new kind of Interbody Cage made of multi-amino acid copolymer/ tri-calcium phosphate（MAACP/TCP） composite was designed,and the purpose of this study was to evaluate immediate stability of MAACP/TCP Cage in a goat cervical spine model（C3-4）.After the motion segment C3-4 was tested intact,27 goat cervical spines were divided into three groups randomly.There were four groups：group A： MAACP/TCP Cage group（n=9）,group B： titanium Cage group（n=9）,group C： autologous tricortical iliac crest bone group（n=9）and group D： intact group（n=27）.Different Cage groups were implanted after complete discectomy（C3-4） was performed.Then they were tested in flexion,extension,axial rotation,and lateral bending with a nondestructive stiffness method.The range of motion（ROM） and relative stiffness were calculated and compared between groups.In comparison to the intact motion segment,MAACP/TCP Cage showed a significantly（P0.05） lower ROM and a significantly（P0.05） higher relative stiffness in flexion and lateral bending.In comparison to the tricortical iliac crest bone graft,MAACP/TCP Cage showed a significantly（P0.05） lower ROM and a significantly（P0.05） higher relative stiffness in extension,flexion and lateral bending.There was no significant（P0.05） difference in the ROM and relative stiffness between MAACP/TCP Cage and titanium Cage in extension,flexion and lateral bending.In comparison to titanium Cage,MAACP/TCP Cage showed a significantly（P0.05） higher ROM and a significantly（P0.05） lower relative stiffness in rotation.Conclusion： MAACP/TCP Cage can provide enough immediate stability for cervical interbody fusion in a goat cervical spine model.

关 键 词：颈椎 椎间融合器 生物力学 

分 类 号：R687.3[医药卫生—骨科学] R318.01[医药卫生—外科学]