基于原子力显微镜技术对血管内皮功能障碍的研究  

A Technical Approach to Endothelial Dysfunction by Atomic Force Microscope

作　　者：陈纤纤[1] 冯烈[1] 

机构地区：[1]暨南大学附属第一医院内分泌科,广州510632

出　　处：《生物医学工程学杂志》2011年第1期184-188,共5页Journal of Biomedical Engineering

摘　　要：血管内皮细胞(ECs)功能众多,易受到血管内的危险因素作用,造成血管内皮功能障碍(ED),目前检测ED的手段仍存在局限性。原子力显微镜(AFM)可在纳米级提供关于细胞表面形态及机械性能的信息,可作为研究ED的新手段。该文对利用AFM研究ED最新进展进行综述。Endothelial cells（ECs） with a variety of functions are vulnerable to attack by various risk factors.These risk factors of vascular pathology lead to endothelial dysfunction（ED）.However,the present methods of evaluating ED have their limitations.Atomic force microscope（AFM）,which can offer the information on the surface images and the mechanical properties of the single cell at nanometer scale,will become a new technical approach to ED evaluation.This review focuses on the recent progress in the application of AFM to assess ED.

关 键 词：血管内皮细胞 血管内皮功能障碍 原子力显微镜 

分 类 号：R319[医药卫生—基础医学]