纳米载体多聚乙烯亚胺介导基因治疗的研究进展  

Progress of Nanometer Vector Polyethylenimine Applied in Gene Therapy

作　　者：陈晓爱[1] 邓宇斌[1] 

机构地区：[1]中山大学中山医学院病理生理学教研室,广州510080

出　　处：《生物医学工程学杂志》2011年第1期195-198,共4页Journal of Biomedical Engineering

基　　金：广东省自然科学基金资助项目(9151503102000023)

摘　　要：阳离子多聚物聚乙烯亚胺(PEI)作为纳米级非病毒类基因转染载体,以其制备简便、可表面修饰、低免疫原性等优势在基因治疗研究中受到广泛关注。本文就PEI应用于体外转染干细胞或靶向递送基因入脑的实验研究进展作一综述,认为聚乙烯亚胺存在细胞毒性及转染效率较低等问题,向纳米材料应用于生物医学领域提出了新的应用要求;但靶向修饰等新兴的材料研发思路为PEI在脑血管疾病基因治疗领域开拓了广阔的应用前景。Polyethylenimine（PEI） is a kind of nanometer nonviral vector frequently applied in gene transfection.It is simple and easy to prepare and to modify and relatively safe compared to viral vectors.In recent years,PEI has been utilized in many research areas for gene delivery to stem cells in vitro or targeted gene delivery to cells in the brain.This review reveales that the cytotoxicity and low transfection efficiency of PEI requires to be improved.However brain-targeted modification indicates the promising prospect of PEI for gene therapy in cerebrovascular diseases.

关 键 词：多聚乙烯亚胺 基因转染 干细胞 脑靶向 

分 类 号：R318.08[医药卫生—生物医学工程]