N-苄基-3-吡咯烷酮合成的研究  

Study on the Synthesis of N-Benzyl-3-Pyrrolidinone

作　　者：李桂花[1] 陈延蕾[1] 钱超[1] 陈新志[1] 

机构地区：[1]浙江大学化学工程与生物工程学系,浙江杭州310027

出　　处：《化学反应工程与工艺》2010年第5期477-480,共4页Chemical Reaction Engineering and Technology

基　　金：国家自然科学基金(21006087);浙江省自然科学基金(Y4100147,Y4090045,R4090358)

摘　　要：以丙烯酸乙酯为原料,经加成、取代、Dieckmann缩合反应、水解之后得到目标产物N-苄基-3-吡咯烷酮。对Dieckmann缩合反应进行了改进,采用钠砂为催化剂,反应收率由44.7%提高到64.0%,并对其它各步的反应条件进行了优化,3-苄胺基丙酸乙酯和3-(N-乙氧羰基亚甲基)苄胺基丙酸乙酯的单步收率分别为96%和93%,四步反应总收率达57.2%,该工艺简单、原料易得、操作简便、收率稳定,适合工业化生产。N-benzyl-3-pyrrolidinone was synthesized starting from ethyl acrylate via addition reaction, substitution reaction, Dieckmann cyclization and hydrolytic decarboxylzation. Starting materials （raw and processed materials） could be obtained easily from commercials, operations were simple and the yields were stable in the technology. The Dieckmann cyclization was improved in the presence of the sodium in the form of granule, and the yield was increased from 44.7% to 64.0% greatly. Other steps of the synthetic reaction were also optimized, and the gross yield of target product was 57. 2% based on ethyl acrylate. This route was better for industrial production of N-benzyl-3-pyrrolidinone.

关 键 词：丙烯酸乙酯 N-苄基-3-吡咯烷酮 Dieckmann缩合反应 

分 类 号：TQ251.3[化学工程—有机化工]