基于隐结构法的更年期综合征常见证候要素的研究  

Research on common syndrome factors of menopausal syndrome based on latent structure method

作　　者：杜彩凤[1] 王天芳[2] 辛意 李力[4] 任婕[5] 吴秀艳[2] 赵燕[2] 薛晓琳[2] 徐雯洁[6] 王智瑜[7] 张连文[8] 王庆国[2] 

机构地区：[1]山西中医学院基础部中医诊断教研室,山西030024 [2]北京中医药大学 [3]北京市回龙观社区卫生服务中心 [4]河南中医学院第一附属医院 [5]北京市石景山区中医医院 [6]首都医科大学附属北京中医医院 [7]中国残疾人联合会就业服务指导中心 [8]香港科技大学

出　　处：《北京中医药大学学报》2010年第12期856-860,共5页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划(973计划)资助项目(No.2003CB517101;No.2003CB517106)

摘　　要：目的运用隐结构法提取更年期综合征的常见证候要素。方法通过多中心、大样本的临床流行病学调查,获取更年期综合征患者的临床四诊信息,按照隐结构法的基本原则进行分析,构建隐结构模型,并在此基础上结合中医专业知识对所获模型进行诠释说明,提取该疾病的常见证候要素。结果获取了1584例更年期综合征患者的临床数据,经数据预处理选择113个显变量,构建了该疾病的隐结构模型,共得到53个隐变量,120个隐类,在结合专业知识进行诠释的基础上,获取67个具有辨证意义的隐类。提取更年期综合征常见证候要素22个,其中病位类证候要素为肝、肾、心、脾、胃、胆、胞宫7个;病性类证候要素为阴虚、阳虚、气虚、血虚、津亏、精亏、气滞、血瘀、血热、热(火)、寒、湿、痰、饮、水停15个。结论隐结构法借助于数学原理,通过分析可直接被观察到的"显变量",挖掘背后左右其的"隐变量",并依据隐变量将事物进行分类,这种模式恰好与中医临床辨证思维基本吻合,为中医证候研究提供了一种切合的数据分析方法。Objective To extract the common syndrome factors of menopausal syndrome（MPS） by using latent structure method.Methods The clinical information of TCM four examinations were collected from patients with MPS by applying multi-center,large sample and epidemiological investigation.The information were analysed according to the basic principle of latent structure method and latent structure model was established.The common syndrome factors were extracted after explaining the obtained model combined with TCM knowledge.Results The clinical data were collected from 1 584 patients with MPS.After data pre-treatment,113 manifest variables were chosen for establishing latent structure model and then 53 latent variables and 120 latent categories were obtained.On the base of explain combined with TCM knowledge,there were 67 latent categories having syndrome differentiation significance,and 22 common syndrome factors of MPS being extracted.Among them there were 7 factors related to disease locations including liver,kidney,heart,spleen,stomach,gallbladder and uterus,and 15 factors related to disease nature including yin deficiency,yang deficiency,qi deficiency,blood deficiency,fluid deficiency,essence deficiency,qi stagnation,blood stasis,blood-heat,heat（fire）,cold,dampness,phlegm,retained fluid and water retention.Conclusion The latent structure method,by using mathematical principles,mines latent variables through analyzing manifest variables and classify things based on latent variables.This model is similar to TCM thinking of clinical syndrome differentiation,and provides a corresponding data analysis method for TCM syndrome study.

关 键 词：隐结构法 证候要素 更年期综合征 

分 类 号：R271.917.5[医药卫生—中西医结合]