两种方法测定10%醋酸磺胺米隆溶液含量的比较  

Comparative Study on Content Determination of 10%Mafenide Acetate Solution by HPLC and UV

作　　者：吴继禹[1] 王志强[1] 张春红[1] 

机构地区：[1]温州医学院附属第一医院,浙江温州325000

出　　处：《中国药业》2010年第24期35-36,共2页China Pharmaceuticals

摘　　要：目的建立测定10%醋酸磺胺米隆溶液含量的高效液相色谱(HPLC)法,并与法定的紫外分光光度(UV)法相比较。方法分别采用UV法和HPLC测定10%醋酸醋酸磺胺米隆溶液的含量,从操作、准确度、精密度等方面比较方法的优劣。结果两种方法的含量测定结果均符合规定。HPLC法的精密度好于UV法。结论 HPLC法简便、快速,与UV法测定结果一致,可作为醋酸磺胺米隆制剂的含量测定方法。Objective To establish a HPLC method for the content determination of 10%Mafenide Acetate Solution and quantitatively compare it with the official UV method.Methods UV and HPLC were respectively adopted to determine the content of 10%Mafenide Acetate Solution and compared in operation,accuracy and precision between the two methods.Results The detection results of the two methods all conformed to the stipulation.The precision of HPLC method was better than that of UV method.Conclusion The HPLC method is simple and rapid with the same detection result of UV method,which can be used to determine the content of mafenide acetate preparation as commonly used hospital preparation.

关 键 词：醋酸磺胺米隆 紫外分光光度法 高效液相色谱法 比较 

分 类 号：R927.2[医药卫生—药学] R978