华蟾素分散片的溶出度测定  

Study on Dissolution Rate of Cinobufotoxin Dispersible Tablets

作　　者：李霞[1] 刘放[2] 吴宏富[1] 

机构地区：[1]浙江省庆元县中医院,浙江庆元323800 [2]浙江省医学科学院药物研究所,浙江杭州310013

出　　处：《中国药业》2010年第24期37-39,共3页China Pharmaceuticals

摘　　要：目的考察华蟾素分散片的溶出度及其体外释药性质。方法照溶出度测定法[2005年版《中国药典(二部)》附录XC溶出度试验法第三法(桨法)],以0.1 mol/L盐酸溶液100 mL为溶出介质,采用紫外分光光度法测定,检测波长为555 nm。结果线性范围为0.409～12.276μg/mL,r=0.999 7(n=7),平均回收率为98.4%～100.5%(n=9),RSD为1.2%～4.8%(n=9)。结论所采用的方法简便、准确、灵敏。该制剂具有良好的溶出度,符合规定。Objective To study the dissolution rate and in vitro releasing characteristics of Cinobufotoxin Dispersible Tablets.Methods The experiment was conducted according to the three method（the paddle method） of dissolution rate test in the appendix XC of China Pharmacopeia（volume Ⅱ,edition 2005）.0.1 mol/L HCl solution 100 mL was used as the mediums for dissolution and the UV spectrophotometric method was adopted for detection with the detecting wavelength of 555 nm.Results The calibration curve of cinobufotoxin Dispersible Tablets was linear within the range of 0.409-12.276 μg/mL,r=0.999 7（n=7）,and the range of recovery rates was 98.4%-100.5%（n=9）,RSD was 1.2%-4.8%（n=9）.Conclusion The method is simple,accurate and sensitive with good dissolution rate,which conforms to the regulation.

关 键 词：华蟾素 华蟾素分散片 溶出度 紫外分光光度法 

分 类 号：TQ461[化学工程—制药化工] R282.74[医药卫生—中药学]