光纤传感技术结合紫外光谱相似度快速分析甲硝唑片  

Rapid analysis of metronidazole tablets by optic-fiber sensing technologies and the similarity of ultraviolet spectra

作　　者：靳露[1] 李莉[1] 李新霞[1] 杨婷[1] 孔彬[1] 许萍萍[1] 

机构地区：[1]新疆医科大学药学院,新疆乌鲁木齐830011

出　　处：《药学学报》2011年第2期203-206,共4页Acta Pharmaceutica Sinica

基　　金：新疆维吾尔自治区科技计划项目(200910107);新疆医科大学硕士研究生创新基金(MC2010-25)

摘　　要：采用光纤传感技术,建立一种光纤传感技术快速分析甲硝唑片的方法。将探头浸入简单处理的药物溶液中,紫外光通过光纤传输到探头,经溶液吸收后由探头反射回光纤,最终由光纤传输到检测系统,计算机显示扫描的紫外吸收光谱,得出药物含量,同时比较该法与药典方法的一致性。数据处理采用紫外全光谱相似度法对比样品图谱与标准图谱的相似性,探索一种新的鉴别药物真伪的方法。本研究结果表明,本法可获得片剂的紫外光谱,含量测定结果与药典方法比较差异无统计学意义(P>0.05),相似度可作为快速分析鉴别药物真伪的参数。The paper is to report the development of an optic-fiber sensing technology method to analyze metronidazole tablets rapidly.In this fiber-optic sensing system,the light from source delivering to probe can be dipped into simple-handling sample solution,absorbed by the solution and reflected to the fiber-optic and detected in the detection system at last.Then the drug content can be shown in the screen from the ultraviolet absorption spectra and the consistency between that obtained by this method and that in China Pharmacopoeia can be compared.With regard to data processing,a new method is explored to identify the authenticity of drugs using the similarity between the sample map and the standard pattern by full ultraviolet spectrum.The results indicate that ultraviolet spectra of tablets can be obtained from this technology and the determination results showed no significant difference as compared with the method in China Pharmacopoeia（P0.05）,and the similarity can be a parameter to identify the authenticity of drugs.

关 键 词：光纤传感 快速分析 甲硝唑 相似度 片剂 

分 类 号：R917[医药卫生—药物分析学]