泊洛沙姆407水溶液的流变学性质  

Rheological properties of poloxamer 407 aqueous solutions

作　　者：胡洁[1,2] 陈大为[1] 全东琴[2] 

机构地区：[1]沈阳药科大学中药学院,辽宁沈阳110016 [2]军事医学科学院毒物药物研究所,北京100850

出　　处：《药学学报》2011年第2期227-231,共5页Acta Pharmaceutica Sinica

摘　　要：本文对泊洛沙姆407(商品名为普朗尼克F127)进行了流变学性质的考察。通过剪切速率触变性实验、温度敏感性实验和多次升温后表观黏度复原性实验得到了泊洛沙姆407各项流变学参数。结果表明,随着泊洛沙姆407水溶液浓度的提高,其由牛顿流体转变为假塑性流体,触变性和胶凝温度均逐渐降低(15.25%泊洛沙姆407可在体温下形成凝胶)。本文为泊洛沙姆407作为凝胶剂基质的应用提供了可参考的流变学数据。Rheological properties of poloxamer 407（brand named Pluronic F127） were examined by changing shear rate,temperature and the recovery properties of apparent viscosity after heating for several times.The results indicated that poloxamer 407 aqueous solution showed a Newtonian behavior at a low concentration while it might be a pseudoplastic fluid when the concentration reached a certain point.The thixotropy and the sol-gel transition temperature decreased with increasing the concentration（it could be an in situ gel at body temperature when the concentration of poloxamer 407 up to 15.25%）.The results that obtained from the rheological data would be useful in the application of poloxamer 407 such as in situ gel preparation.

关 键 词：泊洛沙姆407 流变学 温度敏感 

分 类 号：R943[医药卫生—药剂学]