CCR4及CCR8在子宫内膜异位症患者在位内膜及异位灶的表达  

Expression of CCR4 and CCR8 in eutopic endometrium and ectopic foci of endometriosis

作　　者：罗雪珍[1] 史颖莉[1] 王凌[1] 李大金[1] 

机构地区：[1]复旦大学附属妇产科医院暨妇产科研究所,上海200011

出　　处：《现代妇产科进展》2011年第1期39-41,共3页Progress in Obstetrics and Gynecology

基　　金：国家重大科学研究项目(No:2006CB944007);上海市医学重点学科建设项目(No:05-III016);上海市重点学科建设项目(No:B117);上海市医学领军人才基金项目

摘　　要：目的:检测CCR4及CCR8两种趋化因子受体在子宫内膜异位症患者在位内膜及异位灶组织中的表达特征。方法:以正常子宫内膜为对照,采用免疫组化技术检测内异症患者在位内膜及异位灶组织CCR4及CCR8的表达情况,并比较其差异。结果:正常子宫内膜CCR4及CCR8的表达明显低于内异症患者在位内膜(P<0.05);内异症患者异位灶组织CCR4及CCR8表达明显高于在位内膜(P<0.05)。结论:这些结果提示CCR4及CCR8可能参与内异症的发生及进展。Objective：To evaluate the expression of chemokine receptors CCR4 and CCR8 in the eutopic endometrium and ectopic foci of patients with endometriosis.Methods：Immunohistochemistry was used to detect the protein expression of CCR4 and CCR8 in the eutopic endometrium and ectopic foci of endometriosis,with the endometrium of normal fertile women as control.Results：The expression of CCR4 and CCR8 in the eutopic endometrium was significantly higher than that of the normal endometrium（P0.05）,while the expression of CCR4 and CCR8 in the ectopic foci was significantly higher than that of the eutopic endometrium（P0.05）.Conclusion：Our research indicates that CCR4 and CCR8 is involved in the pathogenesis and development of endometriosis.

关 键 词：子宫内膜异位症 趋化因子受体 CCR4 CCR8 

分 类 号：R711.71[医药卫生—妇产科学]