感染因素对极低出生体重儿胆汁淤积发生率影响的研究  

Investigation of Effect of Infection on Very Low Birth Weight Preterm Infants Associated Cholestasis

作　　者：陈宇辉[1] 文雨琳[2] 

机构地区：[1]郑州市儿童医院新生儿重症监护室,郑州市450052 [2]香港大学玛丽医院初生及儿童深切治疗部

出　　处：《医药论坛杂志》2010年第23期16-17,20,共3页Journal of Medical Forum

摘　　要：目的研究感染因素对极低出生体重儿(VLBWI)发生胆汁淤积的影响作用。方法分析2008年8月—2010年7月郑州市儿童医院新生儿重症监护室(NICU)106例VLBWI的临床资料,对22例发生胆汁淤积和84例无胆汁淤积的VLBW I与感染相关的临床资料进行统计学分析。结果 106例VLBWI胆汁淤积的发生率为20.8%(22/106)。胆汁淤积组在使用抗生素时间、应用机械通气时间、白细胞显著异常例数、血小板明显降低例数、并发坏死性小肠结肠炎例数、血培养阳性例数、痰培养阳性例数的发生率方面均高于无胆汁淤积组(P均<0.05)。结论感染因素是影响极低出生体重儿发生胆汁淤积的危险因素。Objective To investigate the effect of infection on very low birth weight preterm infants associated cholestasis.Methods To retrospectively review the clinical data of the106 extremely low birth weight infants admitted in neonatal intensive care unit of Zhengzhou Children Hospital from August 2008 to July 2010.To compare to the clinical data of 22 of the infants with cholestasis and 84 of the infants with no cholestasis.Results The morbidity of cholestasis in the total of 106 very low birth weight preterm infants is 20.8%（22/106）.There were significant difference in duration of using antibioyics,duration of using ventilation,prominent abnormal in leukocyte,prominent decrease in platelet,associated NEC,positive in blood culture and positive in sputum culture between the infants with cholestasis and the infants with no cholestasis（P〈0.05）.Conclusion Infection is a dangerous factor in very low birth weight preterm infants associated cholestasis.

关 键 词：极低体重儿 感染 胆汁淤积 

分 类 号：R722.19[医药卫生—儿科]