间充质干细胞向软骨分化及在软骨修复中应用的研究进展  

Differentiation of mesenchymal stem cells to chondrocytes and its applications in cartilage repair

作　　者：王立华[1] 刘拥军[1] 

机构地区：[1]中国医学科学院北京协和医学院血液学研究所血液病医院,实验血液学国家重点实验室,天津300020

出　　处：《国际生物医学工程杂志》2010年第6期363-366,371,共5页International Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目（30872618）

摘　　要：关节软骨是一种负重结缔组织,常因肿瘤、运动、退行性变或老年性疾病造成损伤;然而关节软骨自身修复能力有限,给临床治愈软骨缺损造成了很大困难.近些年出现了多种治疗软骨缺损的方法,包括自体软骨细胞移植、微裂缝和镶嵌成形术,但这些方法各自都有其局限性.近年来,组织工程软骨成为软骨修复研究的新热点,间充质干细胞（MSCs）是其当前最有前景的种子细胞.就MSCs在体外诱导分化为软骨细胞的培养条件及MSCs在软骨修复中应用的研究进展进行综述.Articular cartilage as a load-bearing connective tissues may often be caused defects by trauma,sports, degenerative or age-related diseases. As articular cartilage has a limited inherent repair capacity, a large variety of treatment approaches including autologous chondrocyte transplantation, microfracture and mosaicplasty methods have been developed. However, there are limitations in these strategies especially when using autologous chondrcytes. Mesenchymal stem cells are considered the most promising seed cells in the study of tissue engineered cartilage. This review focuses on the induction of mesenchymal stem cells into chondrocytes in vitro and their application in cartilage repair.

关 键 词：间充质干细胞 分化 软骨修复 组织工程 

分 类 号：R6[医药卫生—外科学]