不同方法制备壳聚糖微囊形成机理初探  

Preliminary study on the possible mechanisms of chitosan microcapsules prepared by various methods

作　　者：王玮[1] 金邻豫[2] 白颖[1] 张海峰[1] 许秋菊[1] 

机构地区：[1]河南大学药学院药剂学教研室,河南开封475004 [2]河南大学化学化工学院仿真实验室,河南开封475004

出　　处：《河南大学学报（医学版）》2010年第4期253-257,共5页Journal of Henan University:Medical Science

基　　金：河南大学校内基金项目(04YBRW060)

摘　　要：目的:对不同方法制备壳聚糖微囊的成囊机理进行初步探讨。方法:采用单凝聚法、复凝聚法和乳化固化法分别制备壳聚糖微囊,结合传统理论解释,对相关影响因素进行评价。结果:各种方法成囊机理不同,影响较大的因素也互不相同。结论:通过对这些方法制备壳聚糖微囊成囊机理的研究,可以为优化壳聚糖微囊制备工艺提供理论依据和参考。Objective： To study the possible mechanisms of chitosan microcapsules prepared by various methods preliminarily.Methods： Some chitosan microcapsules were prepared by monophasic coagulation method,complex coacervation method and emulsion crosslinking method,then the evaluation of related factors were conducted through the traditional theory.Results： The sacculation mechanism model and factors varies with different preparation methods.Conclusion： The research on the possible mechanisms will provide a theoretical basis and reference for optimizing technique to prepare chitosan microcapsules.

关 键 词：壳聚糖 微囊 形成 机理 

分 类 号：O636[理学—高分子化学]