不同方法制备壳聚糖微囊体外释放机理初探  

On the possible in vitro release mechanisms of chitosan microcapsules prepared by various methods

作　　者：王玮[1] 许秋菊[1] 白颖[1] 杨浩[1] 张海峰[1] 

机构地区：[1]河南大学药学院药剂学教研室,河南开封475004

出　　处：《河南大学学报（医学版）》2010年第4期261-265,共5页Journal of Henan University:Medical Science

基　　金：河南大学校内基金项目(04YBRW060)

摘　　要：目的:对不同方法制备壳聚糖微囊的体外释放机理进行初步研究。方法:利用直接释药法测定微囊的体外释放度,进行释药方程曲线拟合,并对相关影响因素进行评价。结果:各种方法所制微囊体外累积释放曲线与威布尔方程的拟合结果最理想,初步揭示了微囊结构和释放性能关系的一些规律。结论:通过对不同方法制备壳聚糖微囊体外释放机理的研究,极大地丰富了以壳聚糖作为载体的微囊缓释给药系统的研究内容。Objective： To study the possible in vitro release mechanisms of chitosan microcapsules prepared by various methods.Methods： The in vitro release degree of microcapsule was detected by the directly release method,the medicine releases equation curve was fitted,and the appraisal to the related influencing factors was conducted.Results： When the accumulating in vitro release curve of chitosan microcapsules prepared by various methods was fitted with Weibull equation,the ideal result was received.Some regulations between microcapsule structure and the release property were explored preliminarily.Conclusion： The study on the possible in vitro release mechanisms of chitosan microcapsules prepared by various methods enriches the study on the sustained-release microcapsules delivery system with chitosan as carrier.

关 键 词：壳聚糖 微囊 体外释放 机理 

分 类 号：O636[理学—高分子化学]