中枢神经再生材料研究进展  

Research Progress on Regeneration of Central Nervous System

作　　者：崔福斋[1] 任永娟[1] 于晓龙[1] 

机构地区：[1]清华大学材料科学与工程系再生医学与仿生材料研究所,北京100084

出　　处：《中国材料进展》2010年第12期11-16,共6页Materials China

基　　金：国家973项目子课题(2005CB623905);国家自然科学基金资助项目(50573044和50830102)

摘　　要：首先介绍了目前中枢神经再生面临的问题和应对策略,然后系统地综述了脑再生和脊髓再生修复材料的发展。研究发现,成人中枢神经系统内存的神经干细胞和具有特定分化方向的前体细胞具有潜在的、巨大的修复功能;生物支架材料与神经干细胞的联合使用能够较好地控制细胞微环境,有望提高细胞移植后的存活状况,促进中枢神经再生。最后,结合现在中枢神经再生的研究热点——神经干细胞,阐述了中枢神经再生材料调控干细胞的研究进展和潜能,为联合应用生物材料与干细胞促进中枢再生提供了参考。Current research issues and strategies of central nervous system（CNS） are introduced,and developments on regeneration of brain and spinal cord material are reviewed.It is discovered that neural stem cells in central nervous system and precursor cells with a specific differentiation have a huge potential repair function.The joint use of scaffolds and neural stem cells may better control cellular microenvironment,and is expected to enhance the cell survival state after transplantation and promote regeneration of the central nervous system.Finally,research progress and potentialities on regenerative materials of central nervous system for stem cells controlling are described,considering the research focus now-neural stem cells,which provides a reference for the CNS regeneration combining biomaterials with stem cell materials.

关 键 词：神经再生 组织工程 支架材料 神经干细胞 

分 类 号：R318.08[医药卫生—生物医学工程]