自身抗体联合检测在狼疮性肾炎诊断中的价值  

The value of self-antibodies on diagnosis of lupus nephritis

作　　者：查芳芳[1] 朱迎春[1] 周福健[1] 

机构地区：[1]上海复旦大学附属中山医院青浦分院肾内科,上海201700

出　　处：《西部医学》2011年第2期258-259,共2页Medical Journal of West China

摘　　要：目的探讨抗双链DNA抗体(抗dsDNA)、抗脂蛋白酶抗体(抗LPL)和抗C1q抗体(抗C1q)单项检测和联合检测在狼疮性肾炎(LN)诊断中的价值。方法将77例SLE患者分为A组(LN组,38例)和B组(非LN组,35例),比较抗dsDNA、抗LPL和抗C1q单项及联合检测与LN的关系。结果在A组患者中抗dsDNA、抗LPL、抗C1q单项和联合检测阳性率均显著高于B组(P<0.05)。3种自身抗体联合检测与单项检测比较,敏感性有所降低,但特异性明显提高。结论抗dsDNA、抗LPL和抗C1q联合检测能很好的帮助早期诊断LN。Objective To assess the value of single or combined detection of anti-LPL,anti-dsDNA and anti-C1q antibodies on the diagnosis of lupus nephritis（LN）.Methods 73 patients with SLE were divided into group A（LN group,N=38） and group B（non-LN group,N=35）.The correlations were compared between single or combined detection of three antibodies（anti-LPL,anti-dsDNA and antiC1q） and lupus nephritis.Results The positive rate of single or combined detection of three antibodies in group A was higher than that in group B（P0.05）. The sensibility of combined detection of three antibodies was obviously higher than single detection,while the specificity was lower.Conclusion The combined detection of anti-LPL,anti-dsDNA and anti-C1q antibodies might be helpful for the early diagnosis of lupus nephritis.

关 键 词：狼疮性肾炎 抗脂蛋白酶抗体 抗双链DNA抗体 抗C1Q抗体 

分 类 号：R593.24[医药卫生—内科学]