盐酸洛美沙星大鼠在体肠吸收动力学研究  

Study on intestinal absorption kinetics of lomefloxacin in rats

作　　者：郑雪静[1,2] 赵庆春[1,3] 颜鸣[3] 郑永昌[2] 程刚[1] 

机构地区：[1]沈阳药科大学生命科学与生物制药学院,沈阳110016 [2]沈阳市第一人民医院药剂科,沈阳110044 [3]沈阳军区总医院药剂科,沈阳110840

出　　处：《实用药物与临床》2011年第1期25-27,共3页Practical Pharmacy and Clinical Remedies

摘　　要：目的研究盐酸洛美沙星在大鼠各肠段吸收的药代动力学特征。方法采用大鼠在体肠段灌流实验装置,利用紫外分光光度法和HPLC分别测定酚红和盐酸洛美沙星的含量。结果盐酸洛美沙星在十二指肠、空肠、回肠、结肠的吸收速率常数分别为0.204 5、0.321 0、0.183 9、0.129 2 h-1;在不同药物浓度1.5、15、150μg/mL小肠的吸收速率常数分别为0.192 7、0.219 2、0.230 9 h-1;在不同pH值(6.29、6.79和7.4)时的吸收速率为0.163 1、0.181 9、0.160 2 h-1。结论盐酸洛美沙星在大鼠全肠段均有吸收,吸收符合一级动力学特征,吸收机制为被动转运。Objective To investigate the absorption kinetics of lomefloxacin at different intestine segments in rats. Methods The absorption kinetics was investigated using situ perfusion method in rats.UV and HPLC were used to determine the concentrations of phenol sulfonphthalein and lomefloxacin,respectively. Results The absorption rate constants（Ka）at duodenum,jejunum,ileum and colon were 0.204 5,0.321 0,0.183 9,0.129 2 h-1 respectively;Ka from intestine at lomefloxacin concentration of 1.5,15,150 μg/mL were 0.192 7,0.219 2,0.230 9 h-1;Ka at pH of 6.29,6.79 and 7.4 were 0.163 1,0.181 9,0.160 2 h-1,respectively. Conclusion Lomefloxacin hydrochloride in rat intestines are well absorbed,absorption consistent with a kinetic characteristics of absorption of passive transport mechanism.

关 键 词：盐酸洛美沙星 肠吸收 在体灌流 被动转运 

分 类 号：R965[医药卫生—药理学]