枯芩中清热黄酮类药效组分的测定  

Determination of Active Components Alignments of Flavonoids for Clear Away Heat from Hollow Root of Baikal Skullcap

作　　者：崔萌萌[1] 张贵君[1] 徐蓓蕾[1] 黄睿[1] 

机构地区：[1]北京中医药大学中药学院,北京100102

出　　处：《中国实验方剂学杂志》2011年第4期83-86,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:测定枯芩中4种黄酮类药效组分,为建立黄芩类中药与疗效对应的质量标准提供科学依据。方法:采用药对配伍组分-液相色谱综合分析法。结果:药效组分黄芩苷-黄芩素-汉黄芩苷-汉黄芩素含量为(75.83±7.25),(2.72±0.53),(18.62±2.89),(1.44±0.37)mg.g-1。结论:枯芩中黄酮类药效组分黄芩苷-黄芩素-汉黄芩苷-汉黄芩素,比例为52.44:1.89:12.88:1,有清热燥湿作用,与子芩比较有极显著性差异(P<0.01),建议分别建立黄芩类中药药效组分质量评价指标。Objective：To determine the active components alignments（ACA） of four flavonoids in hollow root of Baikal Skullcap（hollow root of Scutellaria baicalensis）,so as to provide scientific basis for the establishment of quality standard in accordance with its therapeutic.Method：The ACA were determined by reversed phase high-performance liquid chromatography（RP-HPLC） herb-herb compatibility.Result：The content of Baicalin-Baica-lein-Wogonoside-Wogonin in four formulas of hollow root of Baikal Skullcap was（75.83 ± 7.25）,（2.72 ± 0.53）,（18.62 ± 2.89）,（1.44 ± 0.37） mg.g-1.Conclusion：The ACA ratio of flavonoids in hollow root of Baikal Skull-cap was 52.44∶ 1.89∶ 12.88∶ 1,with the action of clearing away lung-heat.There were high significant differences between hollow roots and lateral root of Baikal Skullcap（P 0.01）.Therefore,the quality evaluation criteria of hol-low roots and solid lateral root of Baikal Skullcap should be established separately.

关 键 词：枯芩 黄酮类药效组分 质量评价指标 黄芩类中药 

分 类 号：R284.1[医药卫生—中药学]