高良姜油对胃溃疡小鼠模型血清胃动素、生长抑素、P物质、血管活性肠肽的影响  

Effects of Oils in Alpinia officinarum Hance on Serum Motilin,Somatostatin,Substance P,Vasoactive Intestinal Peptide in Gastrelcosis Mice Model

作　　者：王海燕[1,2] 刘亚明[3] 李海燕[1] 冯前进[3] 郭建友[4] 牛欣[1] 

机构地区：[1]北京中医药大学,北京100029 [2]湖北中医药大学,武汉430061 [3]山西中医学院,太原030024 [4]中国科学院心理研究所,北京100101

出　　处：《中国实验方剂学杂志》2011年第4期105-107,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：科技部国家"十五"攻关计划项目(2004BA721A46);山西省科技攻关项目(2006031082-02)

摘　　要：目的:观察高良姜油对胃溃疡小鼠模型血清胃肠激素的影响。方法:ICR小鼠随机分成7组:正常对照组、模型组、良附丸组(2 g.kg-1)、消旋山莨菪碱片组(0.005 g.kg-1)、高良姜油低、中、高剂量组(2,4,8 mL.kg-1)。预防给药6 d后,采用利血平致胃溃疡小鼠模型,ELISA酶联免疫法测定小鼠血清胃动素(MOT)、生长抑素(SS)、P物质(SP)、血管活性肠肽(VIP)的含量。结果:与模型组相比:①各治疗组均能降低利血平致胃溃疡小鼠模型溃疡指数及提高溃疡抑制率(P<0.01)。②高良姜油高、中剂量组,良附丸组、消旋山莨菪碱片组均能降低胃溃疡小鼠模型血清MOT,SP含量(P<0.01,P<0.05),升高血清SS含量(P<0.01,P<0.05);高良姜油高剂量组能升高血清VIP含量(P<0.01),但中剂量组血清VIP含量变化无统计学意义。结论:高良姜油抗溃疡作用可能与其降低血清MOT,SP的含量,升高血清SS,VIP的含量有关。Objective：To observe effects of oils in Alpinia officinarum Hance（OAOH） on serum gastrointes-tinal hormones in gastrelcosis mice model.Method：ICR mice were randomly divided into 7 groups：control group,model group,liangfu pills group（2 g.kg-1） racanisodimine group（0.005 g.kg-1）,OAOH low dose group,OAOH middle dose group,OAOH high dose group（2,4,8 mL.kg-1）.The gastrelcosis mice model was induced by reser-pine,which was then given drugs for 6 days.The content of motilin（MOT）,somatostatin（SS）,substance P（SP）,va-soactive in testinal peptide（VIP） in serum were determined by ELISA.Result：Compared with the model group：① All the treatment decreased ulcer index and increased ulcer inhibition rate（P 0.01）.②OAOH,liangfu pills,group racanisodimine obviously decreased MOT,SP in serum（P 0.01,P 0.05）,significantly increased SS in serum（P 0.01,P 0.05）;High dose OAOH increased VIP content in serum（P 0.01）.Conclusion：OAOH treats gas-trelcosis by reducing the content of MOT and SP,increaseing the content of SS and VIP in serum.

关 键 词：高良姜油 胃溃疡 胃肠激素 胃肠平滑肌 小鼠 

分 类 号：R285.5[医药卫生—中药学]