参附益心颗粒对慢性心力衰竭大鼠血清心钠素、脑钠素的影响  

Laboratory Observation of Chronic Heart Failure of Shenfu Yixin Granule in Rats

作　　者：王永霞[1] 任红杰[1] 朱明军[1] 张群生[2] 李彬[1] 

机构地区：[1]河南中医学院第一附属医院心脏中心,郑州450000 [2]洛阳市中心医院,河南洛阳471009

出　　处：《中国实验方剂学杂志》2011年第4期118-120,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：河南省科技攻关项目(0624410031);河南省教育厅自然基金(2006360006);"十一五"国家科技支撑计划(2007BAI20B075)

摘　　要：目的:观察参附益心颗粒对慢性心力衰竭大鼠的作用。方法:随机将150只雄性SD大鼠分为造模组130只,假手术组20只。造模组结扎左冠状动脉前降支,假手术组手术方法同上,仅在冠状动脉前降支下穿线不结扎。造模8周后,经超声测定大鼠左室射血分数%(left ventricular ejection fraction,LVEF)<50%者随机分为5组(模型组、卡托普利组、氯沙坦组、参附益心颗粒(5.475,21.9 g.kg-1.d-1)2个剂量组),每组10只,另选假手术组大鼠10只。假手术组及模型组以纯净水ig,药物干预组将药物溶于纯净水中ig给药,每天1次,4周后查LVEF、称重,采血检测指标心钠素(atrial natriuretic peptide,ANP)、脑钠素(brain natriuretic peptide,BNP)。结果:21.9 g.kg-1.d-1参附益心颗粒有明显改善LVEF作用、降低左室重量指数(leftventricular mass index,LVMI)、血清ANP值;参附益心颗粒低高2个剂量组均可显著降低血清BNP值。结论:参附益心颗粒具有明显的抗心力衰竭作用,可能具有干预心室重塑的作用。Objective：To observe the effect of the Shenfu Yixin Granule on chronic heart failure rats.Meth-od：The chronic heart failure model was established by left anterior descending coronary artery occlusion.in sham op-eration group（n = 20） the sutures were passed under the left anterior descending coronary artery without ligation.After 8 weeks the chronic heart failure rats with the value of left ventricle ejection fraction（LVEF） 50% were ran-domly assigned to 5 groups（n = 10 in each group）：model group,captopril group,losartan group,two groups of Shenfu Yixin Granule（5.475,21.9 g.kg-1.d-1）.All the medicine was given through gavage once a day for 4 weeks,the rats in model group and sham operation group were administered with equivalent water once a day for 4 weeks.After 4 weeks The LVEF was valued again with Color Doppler Ultrasound,Weighs were measured.The blood was collected to detection index.Result：Shenfu Yixin granule（21.9 g.kg-1.d-1） improved the LVEF obviously,lowered the left ventricular mass index（LVMI） serum ANP and,serum BNP.Conclusion：Shenfu Yixin granule can cure chronic heart failure evidently and may intervene ventricular remodeling.

关 键 词：参附益心颗粒 慢性心力衰竭 心钠素 脑钠素 心室重塑 

分 类 号：R285.5[医药卫生—中药学]