芪丹益肾降糖胶囊对糖尿病肾病大鼠的保护作用  

Renal Protective Effects of Qidan Yishen Jiangtang Capsule on Diabetic Nephropathy in Rats

作　　者：宫彩霞[1] 王旭璞 高艳峰[1] 韩慈[1] 王占平[1] 

机构地区：[1]石家庄平安医院肾病科,石家庄050012

出　　处：《中国实验方剂学杂志》2011年第4期140-143,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:研究芪丹益肾降糖胶囊对糖尿病肾病(DN)大鼠的保护作用。方法:采用单侧肾脏切除并腹腔注射链脲佐菌素(STZ)的方法复制DN大鼠模型,分为假手术组、模型组、芪丹益肾降糖胶囊(QYJC)组,每组10只,ig给药,每天1次,12周后检测体重(BW)、空腹血糖(FBG)、尿素氮(BUN)、肌酐(SCr)、血清白蛋白(ALB)、总胆固醇(TC)、甘油三酯(TG)、尿蛋白排泄率(UAE);光镜观察肾组织形态学改变并对损害程度进行评分。结果:与模型组相比,QYJC能显著降低DN大鼠的FBG,BUN,TC,TG,UAE,降低肾小球硬化指数和肾小管间质纤维化指数。结论:芪丹益肾降糖胶囊对糖尿病肾病大鼠具有好的保护作用,可能与改善血脂代谢紊乱有关。Objective：To study the renal protective effects of Qidan Yishen Jiangtang Capsule（QYJC）in diabetic nephropathy rats.Method：The DN rats model was established by one side nephrectomy and intraperitoneal injection of streptozotocin.Then rats were randomly divided into 3 groups： sham-operation group,model group,QYJC group,10 in each group.Rats were given the relevant drugs respectively for 12 weeks.Finally the levels of body weight（BW）,fasting blood glucose（FBG）,blood urea nitrogen（BUN）,serum creatine（SCr）,albumin（ALB）,total cholesterol（TC）,triglyceride（TG）,24-hour urinary protein excretion（UPE）were detected.The kidney tissue was taken for histopathological observation and lesion grade.Result：QYJC decreased the levels of FBG,BUN,TC,TG,UAE significantly（P 0.05 or 0.01）,it also reduced glomerulosclerosis index（P 0.05 or 0.01） and tubu-lointerstitial fibrosis index（P 0.05 or 0.01）as compared with DN model group.Conclusion： QYJC has a good re-nal protective effect in rats with diabetic nephropathy.The mechanism may be related to relieving blood lipid metabo-lism disorders.

关 键 词：糖尿病肾病 芪丹益肾降糖胶囊 肾功能 病理形态 

分 类 号：R285.5[医药卫生—中药学]