扶正抗瘤方的辅助抗肿瘤研究  

Experimental Study on Complemental Antitumor Effect of Fuzheng Kangliu Decoction

作　　者：焦河玲[1] 邓虹珠[2] 王晓娟[2] 原海晓[2] 姚辉[2] 姚锐[2] 

机构地区：[1]南阳理工学院,河南南阳473000 [2]南方医科大学中医药学院,广州510515

出　　处：《中国实验方剂学杂志》2011年第4期162-164,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广州市科技计划项目(2006Z2-E5053)

摘　　要：目的:观察扶正抗瘤方对S180荷瘤小鼠的辅助抑瘤作用及免疫调节作用。方法:建立小鼠移植S180肉瘤模型,观察扶正抗瘤方400 mg.kg-1ig连续45 d,对荷瘤小鼠瘤重及免疫学指标的影响。结果:扶正抗瘤方组和环磷酰胺(CTX)组肿瘤生长受到抑制,而且二者合用(联合组)时抑瘤效果显著;扶正抗瘤方联合CTX组胸腺指数、脾指数、吞噬指数、足跖肿胀度与模型组比较均有提高,联合组与CTX比较有显著性差异(P<0.05,P<0.01),扶正抗瘤方组和联合组ALT与荷瘤模型组比较均有下降,与CTX组比较亦有下降(P<0.05);二者尿素氮(BUN)与模型组相比有下降趋势;扶正抗瘤方组自然杀伤细胞(NK)细胞活性高于模型组(P<0.05),而联合组则明显高于模型组及CTX组(P<0.01)。结论:扶正抗瘤方联合化疗药物不仅可以抑制肿瘤生长,还可提高小鼠的免疫功能,具有良好的免疫调节作用。Objective：To observe the complemental antitumor and immunity regulative effect of Fuzheng Kangliu Decoction Method： Sl80 tumor-bearing mice model was established.Tumor weight and immunological inde-xes of Sl80 tumor-bearing mice were observed.Result：The growth of S180 sarcoma in Fuzheng group and cyclophos-phamide（CTX） group was inhibited and the effect with combined drug was more significant.The thymus index,spleen index,phagocytic index and paw edema volume in Fuzheng group and combined drug group were increased compared with the model group.There was significant difference between combined drug group and model group（P 0.05）.The levels of ALT was significantly decreased in Fuzheng group and combined drug group than those in model group（P 0.05）.NK cell activity of Fuzheng group and combined drug group were significantly higher than that in the model group（P 0.05）.Conclusion：Fuzheng Kangliu Decoction combined with anti-tumor chemicals has good immunomodulatory effects which not only inhibit tumor growth but also improve immune function.

关 键 词：扶正抗瘤方 荷瘤小鼠 胸腺指数 脾脏指数 抑瘤率 吞噬指数 

分 类 号：R285.5[医药卫生—中药学]