旱地小单孢菌FIM03-712生物转化雷帕霉素为14-去氧雷帕霉素  

14-deoxorapamycin,the microbial conversion product of rapamycin by Micromonospora chersina FIM03-712

作　　者：李夸良[1,2] 黄捷[1,2] 杨国新[1] 余辉[1] 谢阳[1] 程元荣[1,2] 

机构地区：[1]福建省微生物研究所,福州350007 [2]福建医科大学药学院,福州350004

出　　处：《中国抗生素杂志》2011年第2期117-120,124,共5页Chinese Journal of Antibiotics

基　　金：福建省重点科技项目(2009R10003-2);福建省自然基金资助项目(2009J01076)

摘　　要：在生物转化研究中,获得对雷帕霉素具有转化作用的一株小单孢菌,经分类学研究鉴定为旱地小单孢菌(Micromonospora chersina)FIM03-712。该菌株转化雷帕霉素产生4个化合物,从转化发酵液中分离到一个分子量为900的转化产物,理化性质和波谱分析研究表明,该转化产物为14-去氧雷帕霉素。In-the course of searching for new rapamycin derivatives by microbial conversion, a microorganism, which was able to biotransform rapamycin into four products, was obtained and classified as Micromonospora chersina FIM03-712. One conversion product from the converted broth of the strain was isolated and purified. By means ofphysico-chemical properties and spectral analyses, it was identified with 14-deoxorapamycin.

关 键 词：雷帕霉素 微生物转化 旱地小单孢菌 14-去氧雷帕霉素 

分 类 号：TQ460.38[化学工程—制药化工]