头孢曲松钠结晶诱导期的测定及其晶体生长机理的辨识  

Determination of induction period and crystal growth mechanism of ceftriaxone sodium in acetone-water system

作　　者：张春桃[1] 王海蓉[1] 王永莉[2] 

机构地区：[1]武汉科技大学化学工程与技术学院湖北省煤转化与新型炭材料重点实验室,武汉430081 [2]天津大学化工学院,天津300072

出　　处：《中国抗生素杂志》2011年第2期125-128,共4页Chinese Journal of Antibiotics

摘　　要：采用透射光强法实验测定了288.15K时头孢曲松钠在丙酮-水体系中的结晶诱导期,考察了溶液组成对其结晶诱导期的影响。基于经典的均相成核理论,通过实验测定的诱导期,计算出了头孢曲松钠在丙酮-水体系结晶过程中晶体与母液之间的表面张力和表面熵因子。表面熵因子表明从丙酮-水体系中生长的头孢曲松钠晶体表面粗糙,呈连续生长模式。The induction period, lind, of ceftriaxone sodium crystallized from an aqueous acetone solution at 288.15K was investigated experimentally by an intensity of scattered light method. The effect of the solution composition on the induction period was discussed. Based liquid interfacial tension and surface entropy factor were on the classical homogeneous nucleation theory, the solid- calculated from the induction period data. The values of the surface entropy factor implied that the interface of the ceftriaxone sodium crystal grown from the acetone-water system would be rough and a continuous growth would occur.

关 键 词：头孢曲松钠 诱导期 生长机理 

分 类 号：TQ465.1[化学工程—制药化工]