奥氮平对美国王鸽生产性能的影响及机制研究  

Effect of olanzapine on laying performance of Americal king pigeons and approach to the mechanisms

作　　者：赵文静[1] 顾林英 邹晓庭[1] 张敏[1] 刘进国[1] 

机构地区：[1]浙江大学动物科学学院饲料研究所,浙江杭州310029 [2]浙江欣欣饲料股份有限公司,浙江嘉兴314005

出　　处：《浙江大学学报（农业与生命科学版）》2011年第1期77-82,共6页Journal of Zhejiang University:Agriculture and Life Sciences

基　　金：国家自然科学基金资助项目(30871803);浙江省重大科技专项国际合作资助项目(2008C14074)

摘　　要：采用多巴胺(dopamine,DA)和5-羟色胺(5-hydroxy tryptamine,5-HT)的拮抗剂奥氮平(olanzapine,Ola)作为调控物,研究奥氮平对美国王鸽产蛋性能的影响并探讨其作用机制.选720日龄美国王鸽120对,随机分成4组;对照组饲喂基础日粮,试验组分别添加0.25、0.75和1.25 mg·kg-1奥氮平,试验期60 d.试验结果显示:1)与对照组相比,0.75和1.25 mg·kg-1奥氮平组月产蛋个数分别提高了20.24%(P<0.05)和23.41%(P<0.05),产蛋间隔分别缩短了29.83%(P<0.05)和37.46%(P<0.05),血清总蛋白水平分别提高了7.33%(P<0.05)和11.59%(P<0.05),血清尿素氮水平分别降低了32.6%(P<0.05)和47.8%(P<0.05);2)各组受精率和孵化率差异无统计学意义(P>0.05);0.75和1.25 mg·kg-1奥氮平组血清催乳素水平较对照组分别降低了21.90%(P<0.05)和34.53%(P<0.05),促卵泡生成素水平分别提高了24.0%(P<0.05)和28.5%(P<0.05),血清孕酮水平分别升高了33.7%(P<0.05)和42.0%(P<0.05).表明DA和5-HT的受体拮抗剂奥氮平可以降低血清催乳素(PRL)的分泌,提高促卵泡刺激素和孕酮的分泌,对禽类的就巢发生和维持具有抑制作用;也说明DA和5-HT对禽类就巢的发生和PRL的分泌具有促进作用.This trial was conducted to investigate the effects and mechanism of olanzapine（a antagonist of DA and 5-HT） on laying performance of Americal king pigeons.One hundred and twenty couples of 720-day laying pigeons were randomly allocated to four groups（one control and three treatment groups）,supplied with 0,0.25,0.75 and 1.25 mg·kg-1 olanzapine,respectively.The experiment period was sixty days.Results indicated that： 1） supplement of 0.75 and 1.25 mg·kg-1 olanzapine in diet increased the laying rate by 20.24%（P0.05） and 23.41%（P0.05）,decreased the laying interval by 29.83%（P0.05） and 37.46%（P0.05）,respectively;and the serum concentrations of total protein were significantly increased by 7.33%（P0.05） and 11.59%（P0.05） and blood urea nitrogen level significantly decreased by 32.6%（P0.05） and 47.8%（P0.05） in the 0.75 and 1.25 mg·kg-1 olanzapine groups,respectively;2） different levels of olanzapine had no effect on fecundation and incubation rate of the eggs;compared with the control group,0.75 and 1.25 mg·kg-1 olanzapine groups decreased prolactin concentrations by 21.90%（P0.05） and 34.53%（P0.05）,increased the follicle-stimulating hormone concentrations by 24.0%（P0.05） and 28.5%（P0.05）,and increased the progestin concentrations by 33.7%（P0.05） and 42.0%（P0.05）,respectively.It is indicated that olanzapine,as an antagonist of DA and 5-HT,can promote the laying performance of king pigeon by decreasing the prolactin concentration.

关 键 词：奥氮平 美国王鸽 催乳素 就巢 

分 类 号：S836[农业科学—畜牧学]