一类高活性SOD模拟物的研究  

STUDY ON A KIND OF HIGH ACTIVITY SOD ANALOGUES

作　　者：易筱筠[1] 谢英[2] 自俊青 李大珍[1] 邓希贤[1] 

机构地区：[1]北京师范大学化学系,北京100875 [2]北京医科大学药学院,北京100083

出　　处：《北京师范大学学报（自然科学版）》1999年第2期234-237,共4页Journal of Beijing Normal University(Natural Science)

基　　金：国家自然科学基金!297750115

摘　　要：采用脉冲辐解法分别测得Cu（Thr）2（苏氨酸铜）的不同体系在不同温度下催化O（超氧阴离子自由基）歧化反应的速率常数，算出活化能，并与天然SOD进行了比较．结果发现在相同条件下，C12ThrCu（Ⅱ）（十二酰苏氨酸铜）的活性几乎与天然SOD相当．The systems of Cu(Thr)2 were studied by using pulse radiolysis. The rate constants of the disproportionation for O catalyzed by SOD and its analogues at different temperatures were measured, and the activation energy was obtained. It is found that the SOD like activities of C12 ThrCu(Ⅱ) is even equal tO that of the nature SOD in the same conditions.

关 键 词：SOD模拟物 活性 超氧阴离子 自由基 

分 类 号：Q554.02[生物学—生物化学] R977.3[医药卫生—药品]