1-(2,4-二氨基苯氧基)-3,6-萘二磺酸的简便合成  

A Facile Synthesis of Novel 1-(2,4-Diaminephenoxy)-3,6-naphthalenedisulfonic Acid

作　　者：杜渭松[1] 高嫒嫒[1] 陈沛[2] 安忠维[2] 

机构地区：[1]西安近代化学研究所,陕西西安710062 [2]陕西师范大学化学与材料科学学院应用表面与胶体化学教育部重点实验室,陕西西安710062

出　　处：《精细化工》2011年第2期197-200,共4页Fine Chemicals

基　　金：陕西省科技攻关项目(2009K06-08);教育部回国人员科研启动基金项目~~

摘　　要：以1-萘酚-3,6-二磺酸钠和2,4-二硝基氟苯为原料,通过亲核取代反应制备出侧链磺化二硝基化合物,再经SnCl2/HCl还原反应得到侧链型磺化二胺1-(2,4-二氨基苯氧基)-3,6-萘二磺酸,两步反应总收率为32%。产物结构经IR、1HNMR确认。亲核取代反应的条件研究表明,在二甲基亚砜中室温反应24 h,可制备出液相色谱纯度为98%的侧链磺化二硝基化合物,反应收率为50%。A novel side-chain sulfonated diamine was synthesized through two-step reactions,namely the nucleophilic substitution reaction of 1-naphthol-3,6-disulfonic acid sodium salt to 2,4-dinitrofluorobenzene followed by the reduction under SnCl2/HCl system,which gave an overall yield of 32%.The product was characterized by IR and 1HNMR measurements.The reaction conditions of nucleophilic substitution were investigated.The results showed that the room temperature was prefer to obtain the sulfonated dinitro intermidate with the high purity of 98% and the yield of 50%.

关 键 词：1-萘酚-3 6-二磺酸钠 2 4-二硝基氟苯 磺化二胺 亲核取代反应 精细化工中间体 

分 类 号：TQ246.3[化学工程—有机化工]