C-反应蛋白及代谢综合征与血管病变的相关性研究  

Relationship between C -reactive protein, metabolic syndrome and angiopathy

作　　者：许天蕴[1] 冯龄[1] 陆之瑾[1] 赵秀娥[1] 

机构地区：[1]上海市静安区中心医院内分泌科,200040

出　　处：《中国实用医刊》2011年第4期14-16,共3页Chinese Journal of Practical Medicine

摘　　要：目的 探讨代谢综合征（MS）对2型糖尿病（T2DM）患者血管并发症的影响以及c反应蛋白（CRP）与MS及血管并发症的相关性。方法选取168例T2DM患者，160例MS患者，所有患者均测血压、身高、体重、腰围、臀围、血糖、糖化血红蛋白（HbA1c）、血脂、CRP，用高敏感B超测颈动脉内膜中层厚度（IMT），眼底摄片了解视网膜病变。结果①MS组比T2DM组有更高的冠心病、脑梗死、视网膜病变的发生率，更高的颈动脉IMT，且随着MS组份数的增加而增加。②回归分析显示CRP水平与MS组份数、WHR、空腹血糖（FBG）、收缩压（SBP）呈正相关（β=0．2341，0．201，0．151，0．045；P=0．000，0．001，0．011，0．028）。与高密度脂蛋白呈负相关（B=-0．141，P=0．019），颈动脉IMT与MS组份数、T2DM病程、CRP呈正相关（B=0．328，0．197，0．174；P=0．000，0．001，0．008）。DR与T2DM病程、CRP、SBP呈正相关（β=0．916，0．160，0．023；P=0．000，0．000，0．026）。结论MS与T2DM患者的血管并发症密切相关，而CRP对MS病情的发展及血管并发症有一定的预测价值。Objective To study the effect of aggregation of metabolic syndrome （MS） component on vascular complication in type -2 diabetes mellitus （T2DM） and to study the relationship between high - sensitive C - reactive protein（ CRP）, MS and vascular complication. Methods One hundred and sixty - eight cases of T2DM and 160 cases of MS were included in this study. All subjects were required to have blood pressure, weight, height, waist circumference and hip circumference measured. Serum CRP, glucose and fasting lipids were tested. Body mass index （BMI） and waist - hip - ratio （WHR） were calculated. Intimamedia thickness（IMT） was determined by B mode uhrasonography of high resolution. Non -mydriatic funclus camera screening was carried out in all these patients. Results ①The incidence of coronary artery heart disease, cerebral infarction and diabetic retinopathy （DR） was higher in group MS than in group T2DM. IMT was also higher in group MS than in group T2DM. The higher the number of MS component was, the higher the incidence of coronary artery heart disease, cerebral infarction and DR was. So was with IMT. ②The level of CRP was positively correlated with the number of MS component, WHR, fasting plasma glucose and systolic blood pressure （15 = 0. 2341,0. 201,0. 151, 0. 045; P =0. 000,0. 001,0. 011,0. 028 ）. The level of CRP was negatively correlated with HDL（ β = -0. 141, P =0.019）. IMT was positively correlated with number of MS component, duration of T2DM and CRP （ β =0. 328,0. 197,0. 174 ; P = 0. 000,0. 001,0. 008 ）. The incidence of DR was positively correlated with CRP, duration of T2DM and SBP（ β =0. 916,0. 160,0. 023 ; P =0. 000,0. 000,0. 026）. Conclusions The aggregation of MS component is closely correlated with vascular complication in T2DM. CRP has some predictive value in the development of MS and vascular complication.

关 键 词：C反应蛋白 代谢综合征 血管病变 

分 类 号：R589[医药卫生—内分泌]