乳化-溶剂挥发法制备更昔洛韦药物树脂缓释微囊  

Preparation of ganciclovir-resinate sustained microcapsules by emulsion-solvent diffusion method

作　　者：周伟[1] 谢欢[1] 刘姹[1] 杨大坚[1] 陈新滋[1] 

机构地区：[1]深圳市中药药学及分子药理学研究重点实验室,深圳518057

出　　处：《中国新药杂志》2011年第3期262-266,共5页Chinese Journal of New Drugs

基　　金：深圳市科技计划项目(2D200609180044B)

摘　　要：目的：制备更昔洛韦药物树脂缓释微囊。方法：用三元相图优化乳化-溶剂挥发法的溶剂系统,对微囊的制备工艺及处方进行单因素考察,使用均匀设计优化处方;用Nicomp TM380粒径仪测量微囊的粒径。结果：更昔洛韦药物树脂缓释微囊的最佳制备处方为：乳化体系为液体石蜡∶脂肪酸山梨坦-80∶丙酮（4∶1∶3）;药物树脂与囊材的比例为（5.5∶1）;包衣液RS100浓度为8%;增塑剂浓度为5%。结论：制备出的微囊具有良好缓释效果,12 h的累积释放量达90%以上,微囊颗粒较均匀和圆整,粒径在15~20μm之间。Objective： To prepare ganciclovir-resinate sustained microcapsules.Methods： The solvent system of emulsion-solvent diffusion method was optimized by ternary phase diagram;the single factor of preparation technology and formulation of microcapsule were studied;the formulation was optimized by uniform design.The particle size of microcapsules was measured by Nicomp TM380 grain-size instrument.Results： The optimal ratio of solvent system included liquid paraffin-span80-acetone（4∶1∶3）;the ration of drug-resin and capsule materials was 5.5∶1;the concentration of RS 100 was 8%;the concentration of plasticizer was 5%.Conclusion： The release of microcapsules is satisfactory,and its cumulative release within 12 h is more than 90%.The particles of microcapsule are homogeneous and round,and the particle size is between 15 μm and 20 μm.

关 键 词：乳化-溶剂挥发法 更昔洛韦药物树脂 缓释微囊 均匀设计 

分 类 号：R943.41[医药卫生—药剂学] R978.7[医药卫生—药学]