碱化左旋布比卡因肌间沟臂丛神经阻滞的药代动力学  

Pharmacokinetics of alkalinized levobupivacaine for interscalene brachial plexus block

作　　者：王承海[1] 唐晓莉[1] 尚书军 孙考祥[2] 邵伟[1] 

机构地区：[1]烟台市烟台山医院麻醉科,264008 [2]烟台大学药学院药剂教研室

出　　处：《国际麻醉学与复苏杂志》2011年第1期16-18,共3页International Journal of Anesthesiology and Resuscitation

摘　　要：目的研究pH对左旋布比卡因（1evobupivacaine，LEVO）肌间沟臂丛神经阻滞药代动力学的影响。方法20例择期上肢手术患者，ASAI-Ⅱ级。按随机数字表法随机分为两组，I组（对照组）和Ⅱ组（试验组），分别用0．375％LEVO及其碱化液行肌间沟入路臂丛神经阻滞。于注药前及注药后10、20、30、45、60、90、120、180、240、360、480、720min采血，高效液相色谱法测定LEVO血药浓度。结果两组患者的血药浓度耐间数据经3P97软件进行曲线拟合和模型识别，均符合二房室开放模型。主要药代动力学参数t1/2β、Tmax,Cmax分别为（4．58±0．66）、（4．22±0．37）h；（0．31±0．19）、（0．26±0．18）h和（O．989±0．273）、（1．149±0．317）mg／L。结论LEVO碱化后行臂丛神经阻滞血药浓度升高，但其药代动力学没有发生明显变化。Objective To evaluate the pharmacokinetics of alkalinized levobupivacaine （LEVO） for interscalene brachial plexus block. Methods 20 patients,ASA I -Ⅱ ,undergoing elective upper shoulder surgery were injected hydroehloride or alkalinized LEVO for interscalene brachial plexus block.Venous blood were collected for assay of the total plasma concentration of LEVO immediately before interscalene administration and 10,20,30,45,60,90,120, 180,240,360,480, 720 min after injection. Blood samples were measured by high-performance liquid chromatography. Results The concentration- time curves in two groups were both adequately in line with a two-compartment open model after the curve and model fitting by 3P97 software package.The main pharmaeokinetie parameter such as t1/2/β,Tmax,Cmax was （4.58±0.66）, （4.22±0.37）h;（0.31±0.19）,（0.26±0.18）h and （0.989±0.273）, （1.149 ±0.317）mg/L,respectively. Conclusion The plasma concentration of LEVO is decreased after alkalinized,while its pharmacokinetics does not change.

关 键 词：左旋布比卡因 神经阻滞 臂丛 药代动力学 碱化 

分 类 号：R614[医药卫生—麻醉学]