硫化氢——具有临床应用潜力的气体信号分子  

Hydrogen sulphide---a kind of gas signal molecule for potential clinical application

作　　者：程翅[1] 喻田[1] 

机构地区：[1]遵义医学院麻醉系,563003

出　　处：《国际麻醉学与复苏杂志》2011年第1期64-66,共3页International Journal of Anesthesiology and Resuscitation

基　　金：基金项目：卫生部卫生行业科研查项项目资助（200802173）

摘　　要：背景硫化氢（hydrogen sulphide，H2s）是人们发现的第3个内源性气体信号转导分子，参与了许多疾病的发生发展过程，并且发现H2S相关药物对于某些疾病治疗取得了较为满意的结果。目的总结H2s在中枢神经系统、心血管系统等的作用以及相关机制。内容从中枢神经系统、心血管系统、呼吸系统、消化系统、炎症反应以及其他作用等方面综述近几年来对H2S研究的最新进展，发现H2s可能成为探求病因的一个新方向以及研发相关药物的可能性。趋向随着对H2s认识的加深，H2s相关药物有望成为一种临床用药。Background Hydrogen sulphide （H2S） is the third endogenous gas signal transduction molecule at present, which involved in the development and progression of many diseases. Fairly satisfactory achievement of H2S-related drugs for treatment of certain diseases can be found. Objective To summary the role and related mechanism of hydrogen sulphide in the central nervous system, cardiovascular system et al. Content The review will focus on the latest research on H2S in the central nervous system, cardiovascular system, respiratory system, digestive system, inflammation and other aspect. H2S may be found in a new direction to explore the origin of a disease, and contribute to the possibility of studying new drugs. Trend With the deepening understanding of hydrogen sulfide, HaS-related drugs is expected to be used for clinical application.

关 键 词：硫化氢 气体信号分子 DL-炔丙基甘氨酸 胱硫醚γ-裂解酶 

分 类 号：R363[医药卫生—病理学]