解整合素-金属蛋白酶17在呼吸系统疾病中的研究进展  

Research progress of a disintegrin and metalloproteinase-17 in respiratory diseases

作　　者：李亚清[1] 严建平[1] 许武林[1] 

机构地区：[1]浙江省人民医院呼吸内科,杭州310014

出　　处：《国际呼吸杂志》2011年第4期316-320,共5页International Journal of Respiration

基　　金：基金项目：浙江省医药卫生科学研究基金资助（2008B007）

摘　　要：解整合素金属蛋白酶17（adisintegrinandmetalloproteinase-17，ADAM～17）属于ADAM蛋白酶家族成员之一，又称为肿瘤坏死因子α转化酶，在肿瘤坏死因子α、表皮生长因子等多种跨膜蛋白分子的胞外域剪切脱落过程中起重要作用。ADAM17活性受到转录水平、翻译后修饰及金属蛋白酶组织抑制因子3等多方面调节，活化的ADAM-17在肺癌、重症急性呼吸综合征、慢性阻塞性肺疾病等多种呼吸系统疾病的发生发展中起着重要作用。A disintegrin and metalloproteinase-17 （ADAM-17） is a member of ADAM family, also called tumour necrosis factor-α converting enzyme, plays an important role in the ectodomain shedding of various transmemhrane protein molecules, such as tumour necrosis factor-α and epidermal growth factor. ADAM 17 activity can be regulated by transcriptional level, post-translational modification and tissue inhibitors of metalloproteinases 3. Activated ADAM-17 plays an important role in the development of many respiratory diseases, such as lung cancer, severe acute respiratory syndrome, chronic obstructive puhnonary disease.

关 键 词：解整合素-金属蛋白酶17 胞外域脱落 蛋白水解 

分 类 号：R56[医药卫生—呼吸系统]