阻塞性睡眠呼吸暂停低通气综合征与相关合并症的问卷调查分析  

Questionnaire survey on obstructive sleep apnea hypoventilation syndrome and related complications

作　　者：蔡谦[1] 文卫平[3] 苏振忠[3] 龚未池[3] 邹华[1] 黄至斌[2] 

机构地区：[1]中山大学附属第二医院耳鼻咽喉科,广州510120 [2]中山大学附属第二医院心血管内科 [3]中山大学附属第一医院耳鼻咽喉科医院

出　　处：《中华全科医师杂志》2011年第2期90-92,共3页Chinese Journal of General Practitioners

基　　金：国家“十五”科技攻关计划基金资助（2004BA720A17）

摘　　要：目的探讨阻塞性睡眠呼吸暂停低通气综合征和相关合并症间的相关性。方法2006年3月至6月，采用问卷调查的方式了解本地区1573名常住居民的高血压和打鼾情况，有效问卷1547份。通过多导睡眠监测了解347例中重度打鼾者的阻塞性睡眠呼吸暂停低通气综合征发病情况，同时采用多因素分析筛查高血压的高危因素。结果1547例中高血压184例（11．9％），标化后高血压患病率10．0％，糖尿病49例（2．7％），高血脂212例（10．4％）。结合白天嗜睡症状ESS评分≥9，阻塞性睡眠呼吸暂停低通气综合征患病率为2．2％（34例）。确诊为阻塞性睡眠呼吸暂停低通气综合征的40例中有32．5％患有高血压，远远高于不打鼾组（8．3％）和打鼾组（17．1％）。采用logistic回归分析筛选出年龄、性别、阻塞性睡眠呼吸暂停低通气综合征、糖尿病、高血脂为高血压的高危因素，其中阻塞性睡眠呼吸暂停低通气综合征位居第三。结论阻塞性睡眠呼吸暂停低通气综合征是高血压的高危影响因素之一。Objective To investigate relationship between obstructive sleep apnea hypoventilation syndrome （OSAHS）and hypertension. Methods Questionnaire survey was conducted among 1573 local permanent residents in Guangzhou during March and June 2006 to understand prevalence of hypertension and snoring, and polysomnography monitoring was performed for 347 of them with moderate and severe snoring to estimate prevalence of OSAHS. Risk factors for hypertension was screened with multivariate logistic regression analysis. Results In total, 1547 copies of valid questionnaires were collected, and 184 cases （ 11.9% ） of hypertension were found with a prevalence of 10. 0% , 49 of diabetes with a prevalence of 2. 7% , and 212 of dyslipidemia with a prevalence of 10. 4%. Prevalence of OSAHS was found in 34 of them （2. 2% ） with Epworth sleepiness scale （ESS） score equal to or greater than nine. Prevalence of hypertension in OSAHS group was 32. 5% , much higher than that in non-snoring group （ 8. 3% ） and snoring group （17. 1% ）. Results of logistic regression analysis showed that age, gender, OSAHS, diabetes and dyslipidemia all were high-risk factors for hypertension, with OSAHS ranking the third. Conclusion OSAHS is one of high-risk factors for hypertension.

关 键 词：睡眠呼吸暂停综合征 高血压 问卷调查 

分 类 号：R766[医药卫生—耳鼻咽喉科]