急性心肌梗死不同危险因素人群血脂异常特点  

Association of dyslipidemia and concomitant risk factors in patients of acute myocardial infarction

作　　者：魏勇[1] 欧阳平[1] 汪自龙[1] 沈国英[1] 杨婉花[1] 费民忠[1] 贺茂荣 

机构地区：[1]上海交通大学附属第一人民医院松江分院心内科,201600

出　　处：《中华临床医师杂志（电子版）》2011年第2期231-235,共5页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的分析急性心肌梗死患者的血脂水平,探讨合并不同危险因素的急性心肌梗死患者的血脂水平有无差异及各自的血脂异常特点。方法 2009年5月至2010年5月收集符合入选标准的急性心肌梗死患者110例,检测血脂水平。根据不同危险因素分别将其分为:低龄组与高龄组;男性组与女性组;高血压组与非高血压组;空腹血糖正常组与空腹血糖异常组,将各组内的血脂指标进行对照分析。结果低龄组共73例,其中男51例,女22例;高龄组共37例,其中男17例,女20例。二者的性别比差异有统计学意义(P<0.05)。低龄组TG[(1.47±1.04)mmol/Lvs.(1.05±0.41)mmol/L]、LDL/HDL(2.69±0.92vs.2.32±0.85)和TG/HDL(1.41±1.19vs.0.93±0.45)较高龄组高(P值均<0.05),而其他血脂指标[包括TC、HDL、LDL、TC/HDL、N-HDL、脂蛋白(a)、载脂蛋白A、载脂蛋白B]两组比较差异无统计学意义(P值均>0.05)。急性心肌梗死的男性发病年龄明显早于女性[(63.18±15.04)岁vs.(74.36±11.23)岁,P<0.01]。女性组TC[(4.84±1.25)mmol/Lvs.(4.41±0.94)mmol/L]和HDL[(1.28±0.36)mmol/Lvs.1.09±0.24)mmol/L]均高于男性组(P值均<0.05),其他血脂指标两组比较差异无统计学意义(P>0.05)。急性心肌梗死患者中有58.18%合并有高血压。高血压组与非高血压组比较在性别比和平均年龄上差异均无统计学意义(P>0.05)。高血压组的TC[(4.81±1.09)mmol/Lvs.(4.25±0.99)mmol/L]、LDL[(3.00±0.89)mmol/Lvs.(2.63±0.87)mmol/L]、TG[(1.47±1.10)mmol/Lvs.(1.13±0.46)mmol/L]及N-HDL[(3.61±1.04)mmol/Lvs.(3.13±0.94)mmol/L]均明显高于非高血压组(P值均<0.05),其他血脂指标两组比较差异无统计学意义(P值均>0.05)。空腹血糖正常组与空腹血糖异常组比较在性别比和平均年龄差异无统计学意义,但TC[(4.87±1.18)mmol/Lvs.(4.38±0.97)mmol/L],TG[(1.63±1.24)mmol/Lvs.(1.12±0.50)mmol/L]和TG/HDL(1.52±1.41vs.1.07±0.61),N-HDL[(3.70±1.04)mmol/Lvs.(3.22±0.98)mmol/L]在空腹血糖异常组明显高于空腹血�Objective To test whether there were statistical differences in lipid levels between groups with and without certain risk factor,and further to investigate the association of dyslipidemia and concomitant risk factors in patients of acute myocardial infarction（AMI）.Methods 110 cases of acute myocardial infarction were collected from May 2009 to May 2010.Serum lipid parameters were assayed,such as total cholesterol（TC）,high density lipoprotein（HDL）,low density lipoprotein（LDL）,lipoprotein（a）,apolipoprotein A and apolipoprotein B.All patients were separately divided into four kinds of group according to different risk factors,Younger group and elder group,Male group and female group,Hypertension group and non-hypertension group,Normal fasting blood-glucose（FBG）group and impaired fasting blood-glucose group.Contrast analysis of serum lipid parameters were performed on each group independently.Results Group Younger contained 51 male and 22 female patients,but Group Elder contained 17 males and 20 females.Significant difference（P0.05）were observed in sex ratio between these two groups.Lipid parameters like TG（1.47±1.04）mmol/L vs.（1.05±0.41）mmol/L,LDL/HDL（2.69±0.92 vs.2.32±0.85）and TG/HDL（1.41±1.19 vs.0.93±0.45）were higher in Group Younger than those in Group Elder（P values0.05）,whereas other lipid parameters including TC,HDL,LDL,TC/HDL,N-HDL,lipoprotein（a）,apolipoprotein A and apolipoprotein B showing no difference（P values 0.05）.The onset age of AMI was significantly earlier in Group Male than that in Group Female（63.18 ±15.04）mmol/L vs.（74.36±11.23）mmol/L,P0.01.TC（4.84±1.25）mmol/L vs.（4.41±0.94）mmol/L and HDL（1.28±0.36）mmol/L vs.（1.09±0.24）mmol/L were higher in Group Female than those in Group Male（P values 0.05）,while the other lipid parameters had no statistical difference between the two groups（P values 0.05）.58.18% of AMI patients were concomitant with high blood pressure.There weren＇t statistical differences in

关 键 词：心肌梗死 高脂血症 高血糖症 高血压 

分 类 号：R542.22[医药卫生—心血管疾病]