TPN联合重组人生长激素在腹部大手术的应用  

The research of total parenteral nutrition plus recombinant human growth hormone in patients following major abdominal surgery

作　　者：冉江华[1] 郭群[1] 张家骅[1] 杨炯[1] 王兴贤[1] 徐鹏远[1] 

机构地区：[1]昆明医学院第二附属医院肝胆外一科

出　　处：《肠外与肠内营养》1999年第3期135-137,共3页Parenteral & Enteral Nutrition

摘　　要：目的：研究腹部大手术后联合使用重组人生长激素（ｒｈＧＨ）和ＴＰＮ对病人氮平衡及营养状况的影响。方法：选择２７例接受腹部大手术和完全胃肠外营养的病人，随机分为研究组（１５例）和对照组（１２例），术后连续７天，每天皮下注射重组人生长激素４单位或安慰剂（等渗盐水）。结果：ｒｈＧＨ＋ＴＰＮ显著促进了氮平衡的恢复，提高了血浆白蛋白和转铁蛋白水平，增加了体重和肌酐／身高指数，并降低了血尿素氮，但对肱三头肌皮皱厚度的改变无统计学意义。结论：术后应用重组人生长激素能提高ＴＰＮ支持的疗效。Objectives: To research the effects of using recombinant human growth hormone(rhGH) with total parenteral nutrition(TPN) on nitrogen balance and nutritional state in patients following major abdominal surgery. Methods: We randomly selected 27 patients receiving TPN after major abdominal surgery and distributed them to study group(rhGH+TPN,n=15) and control group(TPN only,n=12).After operation,every one was given rhGH 4U or placebo by hyperdermic injection for 7 days. Results:The results showed that TPN+rhGH increased the nitrogen balance,the level of plasma albumin and transferrin,the body weight and creatinin height index(CHI).But the thickness of triceps skin fold(TSF) had no significant change. Conclusions: The rhGH can improve the effects of TPN.

关 键 词：重组人生长激素 肠外营养 腹部大手术 氮平衡 

分 类 号：R459.3[医药卫生—治疗学] R656.05[医药卫生—临床医学]