肠内营养制剂IMPACT对创伤大鼠免疫功能的影响  

Effects of enteralnutrient IMPACT on immune function of traumatic rat

作　　者：张利华[1] 张小桥[1] 黎介寿[1] 

机构地区：[1]南京军区南京总医院解放军普通外科研究所

出　　处：《肠外与肠内营养》1999年第3期147-149,共3页Parenteral & Enteral Nutrition

摘　　要：目的：旨在观察含有免疫促进作用营养物质（精氨酸、鱼油及核苷酸）的肠道营养制剂ＩＭ－ＰＡＣＴ对创伤后免疫抑制机体的免疫调节作用。方法：用双侧股骨骨折的创伤大鼠２１只，随机分为ＥＮＳＵＲＥ组、ＮＵＴＲＩＳＯＮ组和ＩＭＰＡＣＴ组进行肠道营养支持。肠道营养用量为８３７ｋＪ（２００ｋｃａｌ）／（ｋｇ·ｄ），以灌胃的方法提供营养，共５天。实验前后观察体重、血常规、血白蛋白、外周血Ｔ淋巴细胞亚群分类和脾光镜标本的定量分析。结果：创伤后三组大鼠体重及血清白蛋白均下降，接受肠内营养ＩＭＰＡＣＴ组大鼠的免疫功能指标较其他两组有明显增强。结论：含有免疫促进作用营养物质的肠内营养制剂，可改善创伤后机体受抑制状态的免疫功能。Objectives: To evaluate the immunomodulatory effect of enteral nutrient IMPACT,containing immunomodulator argininefish oil and RNA,on the postraumatic immunosuppression of organism. Methods:The traumatic models were established by bilateral femoral fracture in 21 Wistar rats.They were devided into 3 groups randomly according to the different nutrient:Ensure group,Nutrison group and Impact group.They were all fed intragastrically with each enteral nutrient which provides 837 kJ/kg per day for 5 days.The changes of body weight,serum albumin,peripheral blood T lymphocyte subsets and blood routine examination,quantitative microscopy of spleen were analysed. Results: Body weights and serum albumin levels of 3 groups decreased after trauma.In rats fed with IMPACT,the indexes of immune function were improved significantly. Conclusions: The posttraumatic immunosuppression can be corrected by enteral nutrient containing immunomodulator.

关 键 词：创伤 肠内营养 免疫功能 IMPACT 

分 类 号：R459.3[医药卫生—治疗学] R641.05[医药卫生—临床医学]