脑脉舒宁对小鼠急性脑缺血保护作用的实验研究  

Protective effect of Naomaishuning(NMS) on the experimental acute cerebral ischemia in mice

作　　者：王淑英[1] 李艳 周颖红[2] 王建刚 许晓霞 路西明 

机构地区：[1]洛阳医专药理教研室,洛阳4710032 [2]洛阳医专生理教研室,洛阳4710033 [3]开封医专第一附属医院,开封475000

出　　处：《洛阳医专学报》1999年第2期102-103,共2页Journal of Luoyang Medical College

基　　金：河南省科技攻关项目

摘　　要：目的　观察脑脉舒宁 (NMS)对小鼠脑缺血损伤的保护作用。方法　采用小鼠双侧颈总动脉和迷走神经结扎法制作脑缺血模型并观察NMS对其的影响。结果　急性脑缺血时脑内丙二醛 (MDA)、一氧化氮 (NO)明显增加 (P <0 .0 5 )。超氧化物歧化酶 (SOD)减少 ,而NMS可明显增加SOD ,降低MDA、NO(P <0 .0 5 )。结论　NMS对小鼠急性脑缺血具有一定保护作用。Objective To observe the protective effects of NMS on cerebral ischemia reperfusion injury. Methods The method of ligating both common carotid arteries and vagus nerves was used to make acute cerebral ischemia reperfusion injury in mice. Results NMS increased notably brain SOD content,and at the same time decreased brain MDA and NO content on the cerebral ischemia (P<0.05). Conclusion NMS may have protective effect on the cerebral ischemia injury in mice.

关 键 词：脑脉舒宁 脑缺血 中医药疗法 

分 类 号：R285.5[医药卫生—中药学] R277.733.1[医药卫生—中医学]