温阳通督中药结合理筋手法对颈脊髓机械性压迫损伤家兔模型血液流变学的影响  

Effects of "Wenyang Tongdu" Chinese Herbs Combined with Tendon-regulating Manipulation on Hemorheology in Rabbits with Spinal Cord Injury due to Mechanical Compression

作　　者：陈博[1] 林勋[1] 詹红生[1] 石印玉[1] 赵咏芳[1] 王翔[1] 徐宇[1] 郭海玲[1] 

机构地区：[1]上海中医药大学附属曙光医院上海市中医药研究院骨伤科研究所,上海200021

出　　处：《上海中医药大学学报》2011年第1期49-52,共4页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划("973"计划)资助项目(2007CB512701);教育部重点学科建设资助项目(100508);国家中医药管理局重点专病专科项目(09J1X1L116K110);国家中医药管理局"治未病"专项项目(09411953400);中医药行业科研专项(7-17);上海市重点学科建设项目(T0303);上海市科委重点项目(09411953400;09dZ1973800);上海市领军人才队伍建设项目;上海高校创新团队建设项目(2009-26);上海申康医院发展中心项目(SHDCI2007215);浦东新区中医领军型人才项目(PWZ12008-20-101);浦东新区科技发展基金创新资金攻关项目(PKJ2008-y08)

摘　　要：目的:探讨温阳通督中药结合理筋手法对颈脊髓机械性压迫损伤家兔模型血液流变学的影响。方法:选用新西兰大白兔60只,在家兔C5椎体上植入不锈钢螺钉,建立家兔颈脊髓机械性压迫损伤模型,术后观察两个月并进行Tarlov评分后,将造模家兔随机分为中药加手法组、中药组、弥可保组和对照组,前三组予手法及药物干预,两个月后颈总动脉取血检测全血黏度、红细胞压积和红细胞聚集指数等血液流变学指标。结果:中药加手法组和中药组在200/s,30/s,5/s,1/s剪切速率下与对照组及弥可保组相比,全血黏度均明显降低(P<0.05);弥可保组在5/s剪切速率下与对照组相比全血黏度降低(P<0.05),而中药加手法组在5/s剪切速率下与中药组相比全血黏度降低(P<0.05)。中药加手法组和中药组的红细胞压积明显低于对照组与弥可保组(P<0.05);中药加手法组、中药组和弥可保组的红细胞聚集指数低于对照组(P<0.05)。结论:温阳通督中药结合理筋手法对慢性机械性压迫造成的脊髓损伤具有降低血液黏稠度、减轻红细胞压积、降低红细胞聚集指数的作用。Objective： To explore the effects of ＂Wenyang Tongdu＂Chinese herbs combined with tendon-regulating manipulation on hemorheology in rabbits with spinal cord injury due to mechanical compression.Methods： Sixty New Zealand rabbits were selected and the rabbit model of spinal cord injury due to mechanical compression was established by implanting stainless steel screw into the C5.The Tarlov score was observed two months after operation,and all the model rabbits were randomly divided into Chinese herbs with manipulation group（A）,Chinese herbs group（B）,Methylcobal group（C） and control group（D） and the three former groups were treated by corresponding methods.The whole blood viscosity,hematocrit and erythrocyte aggregation index were detected two months after treatment.Results： The whole blood viscosity at the shear rate of 200/s,30/s,5/s and 1/s significantly decreased in group A and group B compared with group C and group D（P0.05）;the whole blood viscosity at the shear rate of 5/s in group C was lower than that in group D（P0.05）,and the whole blood viscosity at the shear rate of 5/s in group A was lower than that in group B（P0.05）.The hematocrit in group A and group B was lower than that in group C and group D（P0.05）;the erythrocyte aggregation index in groups A,B and C was lower than that in group D（P0.05）.Conclusion： ＂Wenyang Tongdu＂ Chinese herbs combined with tendon-regulating manipulation can decrease the blood viscosity,hematocrit and erythrocyte aggregation index in rabbits with spinal cord injury due to mechanical compression.

关 键 词：温阳通督 中药 理筋手法 脊髓损伤 血液流变学 

分 类 号：R285.5[医药卫生—中药学] R744[医药卫生—中医学]