抗早2号方对青春期雌性大鼠骨骼生长的影响  

Effects of "Kangzao-Ⅱ Decoction" on Skeletal Growth in Puberty Female Rats

作　　者：赵鋆[1] 赵咏芳[2] 朱敏华[1] 卓跃红[1] 

机构地区：[1]上海中医药大学附属曙光医院,上海201203 [2]上海中医药大学附属曙光医院骨伤科研究所,上海201203

出　　处：《上海中医药大学学报》2011年第1期68-71,共4页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：上海市教委科研基金资助项目(06CZ009)

摘　　要：目的:研究抗早2号方对青春期雌性大鼠骨骼生长的影响和作用机制。方法:120只SD大鼠随机分为治疗组、中药对照组、西药组、空白组4组。用药4周,停药2周,每3周采样1次,观察抗早2号方对青春期雌性大鼠胫骨长度、宽度、骨密度及尿吡啶酚(PYD)和血清I型胶原前胶原C端肽(PICP)的影响。结果:停药2周时,治疗组与空白组比较,血清PICP降低(P<0.05),尿中PYD含量减少(P<0.05),股骨密度、腰椎骨密度、胫骨长径、宽径差异均无统计学意义(P>0.05);与中药对照组比较,血清PICP增高(P<0.05),尿中PYD含量无明显差异(P>0.05),股骨密度显著降低(P<0.01),腰椎骨密度降低(P<0.05);与西药组比较,血清PICP、尿中PYD、股骨和腰椎骨密度、胫骨长径、宽径差异均无统计学意义(P>0.05)。结论:抗早2号方能抑制青春期雌性大鼠骨骼的快速生长,同时维持骨矿含量的稳定。Objective： To study the effects of ＂Kangzao-Ⅱ Decoction＂ on skeletal growth in puberty female rats and its mechanism.Methods： One hundred and twenty SD Rats were randomly divided into four groups： ＂Kangzao-Ⅱ Decoction＂ group,＂Zhibai Dihuang Decoction＂ group,western medicine group,and negative control group.The course of drug administration was four weeks and then the treatment was stopped for two weeks.The samples were collected once every three weeks and the length and width of tibia,the density of bone,urinary pytidol（uPYD） and procollagen type I carboxy terminal propeptide（PICP） were observed.Results： After drug discontinuation for two weeks,compared with the negative control group the levels of PICP of serum and uPYD significantly decreased in ＂Kangzao-Ⅱ Decoction＂ group（P0.05）,and there was no statistical difference on the density of femur and lumbar vertebra and the length and width of tibia between the two groups（P0.05）;compared with the ＂Zhibai Dihuang Decoction＂ group,the level of PICP increased（P0.05）and the density of femur and lumbar vertebra significantly decreased in ＂Kangzao-Ⅱ Decoction＂ group（P0.05 or P0.01）;there was no statistical difference on the levels of PICP and uPYD,the density of femur and lumbar vertebra,and the length and width of tibia between the ＂Kangzao-Ⅱ Decoction＂ group and western medicine group（P0.05）.Conclusion： ＂Kangzao-Ⅱ Decoction＂ can inhibit the bone growth of the puberty female rats and maintain the stability of bone mineral content.

关 键 词：中药 抗早2号方 青春期 大鼠 骨代谢 

分 类 号：R285.5[医药卫生—中药学]