阿德福韦酯联合苦参素胶囊治疗HBeAg阳性慢性乙型肝炎临床观察  

Adefovir dipivoxil and oxymatrine combination therapy in treatment of patients with HBeAg - positive chronic hepatitis B

作　　者：阎振武[1] 李淑花[1] 陈建红[1] 高凤至[1] 王万朋[1] 

机构地区：[1]山东省潍坊市人民医院传染科,261041

出　　处：《中国实用医刊》2011年第5期31-33,共3页Chinese Journal of Practical Medicine

摘　　要：目的观察阿德福韦酯和苦参素联合治疗HBeAg阳性慢性乙型肝炎患者的疗效。方法将132例HBeAg阳性的慢性乙型肝炎患者随机分为联合治疗组70例，给予阿德福韦酯10mg／d，苦参素胶囊450mg／d；单用组62例，仅给予阿德福韦酯治疗。观察治疗12周、24周、52周时应答反应情况。结果肝功能复常率在12周时联合组优于单用组（P〈0．05），在24周、52周时差异无统计学意义（P〉0．05）。联合组和单用组HBVDNA阴转率12周时分别为22．2％和20．0％，24周时分别为36．1％和31．6％，两组比较差异无统计学意义（P〉0．05），但52周时别为61．1％和46．7％，两组比较差异有统计学意义（P〈0．05）；联合组和单用组HBeAg／HBeAb血清转换率在12周时分别为6．9％和5．0％，两组比较差异无统计学意义（P〉0．05），但在第24周（分别为22．2％、11．7％）、第52周（分别为40．2％、20％）时，两组比较差异有统计学意义（P〈0．05，P〈0．01）。两组患者在治疗过程中，均未发现明显不良反应。结论阿德福韦酯和苦参素联合应用能显著提高对HBeAg阳性慢性乙型肝炎患者的抗病毒疗效。Objective To evaluate the efficacy of adefovir dipivoxil and oxymatrme combination therapy in treatment of patients with HBeAg- positive chronic hepatitis B （CHB）. Methods One hundred and thirty -two patients with HBeAg- positive CHB were randomly divided into two groups ：70 pa- tients in combination therapy group were given adefovir dipivoxil 10 mg/d and oxymatrine 450 rag/d,62 patients in adefovir dipivoxil monotherapy. Evaluation were performed at week 12,24 and 52,respective- ly. Results At week 12 ,the normalization rate of aminotransferase in combination group was higher than it in monotherapy group （ P 〈 0.05 ） , but there was no difference between the two groups at week 24 （P 〉 0.05） and 52 （ P 〉 0.05）. The HBV DNA undetectable rate in combination group and monothera- py group was 22.2% and 20.0% at week 12（ P 〈0.05） ,36.1% and 31.6% at week 24（ P 〈0.05）, 61.1% and 46.7% at week 52（ P 〉0.05）. The seroconversion rate of HBeAg/HBeAb in combination group and monotherapy group were 6.9% and 5.0% at week 12 （ P 〉0.05） ,but it differed between the two groups at week 24（22.2% VS 11.7%, P 〈0.05 ）and at week 52 （40.2% VS 20%, P 〈 0.05 ）. No severe adverse reaction was found in both groups. Conclusions Adefovir dipivoxil and oxymatrine combination therapy could enhance the antiviral effects in patients with HBcAg -positive CHB.

关 键 词：阿德福韦酯 苦参素 乙型肝炎 慢性 药物疗法 联合 

分 类 号：R512.62[医药卫生—内科学]