不同治疗因素对阿德福韦抗乙肝病毒作用的影响  

Different factors on Adefovir antiviral effects in patients with chronic hepatitis B

作　　者：王荣荣[1] 王艳[1] 赵龙凤[1] 任娇龙[1] 

机构地区：[1]山西医科大学第一医院感染病科,太原030001

出　　处：《中国医疗前沿》2011年第1期31-32,共2页China Healthcare Innovation

摘　　要：目的探讨慢乙肝(CHB)患者HBeAg、ALT水平及既往干扰素α-2b(IFNα-2b)抗病毒治疗史等不同因素对阿德福韦酯(ADV)抗病毒作用的影响。方法选择CHB患者43例,给予口服ADV 10mg/d抗病毒治疗,定期检测HBV DNA及生化指标等,观察2年。结果 ADV对HBeAg阴性组抑制病毒效果优于阳性组(P<0.001);ALT分组比较P=0.642,无统计学意义;有IFNα-2b治疗史组HBV DNA平均下降水平高。结论 ADV对HBeAg阴性组病毒抑制效果优于阳性组,ALT水平不影响核苷类似物的抗病毒作用,慢乙肝患者既往有IFNα-2b治疗史有利于病毒转阴。Objective Observe HBeAg,ALT situation and past anti-viral history of the different treatment on antiviral effect of Adefovir（ADV）.Methods 43 patients with chronic hepatitis B（CHB） were included,oral administration of ADV 10mg/d,periodicly detect HBV DNA and Biochemical,observed for two years.Results Group of HBeAg-negative viral inhibition effect is significantly better than the positive group;ALT group comparison P=0.642,no statistically significant;the HBV DNA of with IFNα-2b therpy history group is lower.Conclusions The effect of ADV in HBeAg-negative group is better than the positive group,ALT levels do not affect the antiviral activity of nucleoside analogues For CHB swilling to ADV,with IFNα-2b treatment is benetit to virus negative.

关 键 词：阿德福韦酯 干扰素Α-2B 核苷酸类似物 抗病毒 

分 类 号：R512.62[医药卫生—内科学]