外科危重病患者凝血障碍的动态变化  

Dynamic change in blood coagulation in critically ill surgical patients

作　　者：刘牧林[1,2,3] 方先业 鲍子雨[1,2,3] 昌茂岭 

机构地区：[1]蚌埠医学院附属医院急诊外科 [2]蚌埠市第一人民医院普外科 [3]蚌埠市第三人民医院普外科

出　　处：《蚌埠医学院学报》1999年第3期143-144,共2页Journal of Bengbu Medical College

摘　　要：目的：探讨外科危重病患者凝血功能障碍与病情严重度和预后的关系。方法：７１例外科危重症患者分为轻型组、重型组、死亡组，发病０、４、８ｄ分别检测抗凝血酶Ⅲ（ＡＴⅢ）、组织型血浆纤溶酶原激活物（ｔＰＡ）、组织型血浆纤溶酶原激活物抑制剂（ＰＡＩ）、血小板α颗粒膜蛋白（ＧＭＰ１４０）。结果：危重症患者凝血和纤溶系统被激活，并伴有纤溶受抑，死亡者与存活者差异有显著性（Ｐ＜０．０１），并与疾病严重度和预后有一定的相关性。结论：动态监测止凝血指标有助病情的判断和预后的估计。Objective:To investigate the blood coagulation disorder in critically ill surgical patients.Methods:Seventy one cases were divided into mild,severe and dead groups.All patients were measured for AT Ⅲ,t PA,PAI,GMP 140 on 0,4 and 8 days after admission.Results:The coagulation and fibrinolysis were activated,and fibrinolysis was inhibited.There is a significant difference between survivors and nosurvivors( P <0.01).These changes are closely correlated with the APACHE Ⅱ score.Conclusions:Change in coagulation parameters is important in evaluating the condition and prognosis of critically ill surgical patients.

关 键 词：危重病人 监护 外科急症 凝血障碍 

分 类 号：R605.97[医药卫生—急诊医学] R473.6[医药卫生—外科学]