HPLC测定犬血中抗肿瘤化合物8-氯腺苷的药代动力学  

RP HPLC determination of pharmacokinetics of 8 Cl A an anticancer compound in dog body

作　　者：王欣宇[1,2] 张蔚青[1,2] 朱凤坤[1,2] 邹安庆[1,2] 许昀[1,2] 楼雅卿[1,2] 

机构地区：[1]北京医科大学药学院 [2]北京医科大学基础医学院药理系

出　　处：《中国药学杂志》1999年第5期321-323,共3页Chinese Pharmaceutical Journal

摘　　要：目的：测定８－氯腺苷（８－Ｃｌ－Ａ）及其代谢物８－Ｃｌ－Ａｄ和８－Ｃｌ－Ⅰ在犬血中的药动学。方法：用ＲＰ－ＨＰＬＣ测定犬血中和组织中８－Ｃｌ－Ａ及其代谢物。结果：犬单剂量和多剂量静脉点滴８－Ｃｌ－Ａ后，计算得到８－Ｃｌ－Ａ的代谢物８－Ｃｌ－Ａｄ的药动学参数。结论：８－Ｃｌ－Ａ在犬体内迅速代谢和消除血中未出现蓄积性现象，８－Ｃｌ－Ａ在犬体内主要以８－Ｃｌ－Ａｄ代谢物分布于主要脏器组织中。OBJECTIVE:To determine the pharmacokinetics of 8 Cl A and its main metabolited,8 Cl Ad and 8 Cl I,in dogs.METHOD:A simple and accurate RP HPLC method was used to determine 8 Cl A and its metabolites in blood and tissues.RESULTS:The main pharmacokinetic parameters of 8 Cl Ad in dogs were obtained after single dose and multiple dose iv infusion of 8 Cl A in dogs.CONCLUSION:The parent compound,8 Cl A,was rapidly and completely biotransformed into its main metabolite 8 Cl Ad and then 8 Cl Ⅰ 8 Cl A and its metabolites had no accumulative effect in blood.8 Cl A was mainly biotransformed into 8 Cl Ad which distributed in many organs and tissues in dogs.

关 键 词：8-氯腺苷 药代动力学 抗癌药 高效液相色谱法 

分 类 号：R979.1[医药卫生—药品]