解脲支原体与胎儿宫内发育迟缓关系的探讨  

Study of Relation between Ureaplasma Urealyticum and Fetal Intrauterine Growth Retardation

作　　者：周怀君[1] 李明发[1] 程云英[1] 单祥年[1] 

机构地区：[1]南京铁道医学院妇产科教研室

出　　处：《中华妇产科杂志》1999年第5期284-286,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的探讨孕妇感染解脲支原体对胎儿宫内发育的影响。方法采用聚合酶链反应（ＰＣＲ）技术，分别对新生儿出生体重小于２５００ｇ的５０例孕妇的宫颈分泌物、新生儿脐血及胎盘（试验组）和正常新生儿出生体重的５０例孕妇的宫颈分泌物、新生儿脐血及胎盘进行解脲支原体检测（对照组），并对两例胎盘进行常规病理检查。结果试验组新生儿脐血、胎盘解脲支原体的感染例数（３３例）明显高于对照组（７例），两者比较，差异有显著性（Ｐ＜０．０５）。两组宫颈分泌物感染例数比较（３７例∶３０例），差异无显著性（Ｐ＞０．０５）。试验组有１２例发生胎盘绒毛膜羊膜炎，而对照组仅有４例，两者相比，差异有显著性（Ｐ＜０．０５）。试验组胎盘病理检查显示，解脲支原体感染的胎盘有绒毛膜羊膜炎１０例；无解脲支原体感染的胎盘有绒毛膜羊膜炎３例，两者比较，差异有显著性（Ｐ＜０．０５）。结论解脲支原体可感染胎盘、脐血，影响胎儿宫内发育，是造成胎儿宫内发育迟缓的原因之一。Objective To study the influences of Ureaplasma Urealyticum (UU) infection to fetal intrauterine growth. Methods Polymerase Chain Reaction was used to detect UU in samples of cervical secretions, umbilical blood and placenta. The study group included 50 women with neonatal birth weight below 2 500 g, 50 women with newborns birth weight above 2 500 g served as control group. Results Positive rate of UU in samples of cord blood and placenta and placental chorioamnionitis in study group were higher than that in the control group (P<0.005 and P<0.05). There was no significant difference of UU positive rate in cervical samples between two groups. The positive rate of UU in cases with chorioamnionitis was higher than that of cases with negative UU infection (P<0.05). Conclusion UU may interfere fetal intrauterine growth through infecting umbilical blood and placenta.

关 键 词：胎儿 宫内发育迟缓 解脲支原体 

分 类 号：R714.431[医药卫生—妇产科学] R375.3[医药卫生—临床医学]