载脂蛋白M与动脉粥样硬化的研究进展  

Recent advances in apolipoprotein M and atherosclerosis

作　　者：刘杨[1] 张晓膺[1] 罗光华[2] 

机构地区：[1]苏州大学附属第三医院心胸外科,江苏常州213003 [2]苏州大学附属第三医院综合实验室,江苏常州213003

出　　处：《中国病理生理杂志》2011年第1期200-203,208,共5页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.30972955)

摘　　要：心、脑血管疾病的发生率及死亡率居各种疾病前列,动脉粥样硬化（atherosclerosis,AS）是其重要的病理基础,因此对动脉粥样硬化的研究具有极其重要的临床意义。动脉粥样硬化研究范围广泛,近年来,载脂蛋白与动脉粥样硬化关系的研究进展尤为迅速。Atherosclerosis is a complex pathological process,which has a close relationship with inflammatory response and disorder of lipid metabolism.The cardioprotective role of high-density lipoprotein（HDL） is related to its characters of protecting the vascular endothelial cells and the properties of anti-inflammation and anti-oxidation.Low-density lipoprotein（LDL） and very-low-density lipoprotein（VLDL） are thought to have the adverse effects on human atherosclerosis.Apolipoprotein M（apoM,found in 1999） is an apolipoprotein mainly associated with HDLs.ApoM has a remarkable property of anti-atherosclerosis in animal experiment.However,recent studies have not yet been able to establish that apoM is a defining risk factor for human coronary heart disease,and the biological functions of apoM,including its potential role in human atherogenesis,need to be established.

关 键 词：载脂蛋白M 动脉粥样硬化 脂蛋白M HDL 脂质代谢 

分 类 号：R541.4[医药卫生—心血管疾病]