蒙古族和汉族正常志愿者单剂量口服替硝唑的药代动力学研究  

THE STUDY OF PHARMACOKINETICS OF SINGAL ORAL DOSE TINIDAZOLE IN MONGOLIAN AND HAN HEALTHY VOLUNTEERS

作　　者：王毅[1] 孟根达莱[1] 孙明[1] 任显华[1] 钮鑫[1] 郭智[1] 

机构地区：[1]内蒙古医学院附属医院

出　　处：《中国临床药理学杂志》1999年第3期197-198,227,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：健康男性志愿受试者１６人（蒙古族８名，汉族８名）每人单剂量口服替硝唑２ｇ，采用高效液相色谱法测定血药浓度，研究其药代动力学过程。结果表明：蒙、汉族替硝唑药代动力学参数分别为Ｔ１／２（Ｋａ）：０．８６±０．５ｈ和１．２２±０．１２ｈ；Ｔ１／２（Ｋｅ）：１４．７３±４．３３ｈ和１３．０４±１．４４ｈ；Ｔｐｅａｋ：３．３５±１．８１ｈ和４．１２±１．５４ｈ；Ｃｍａｘ３８．８９±７．８０ｍｇ·Ｌ－１和３７．５８±３．９７ｍｇ·Ｌ－１；Ｖ／Ｆ：４３．５８±３．９０Ｌ和４５．６０±８．４０Ｌ。蒙、汉两组的各项药代动力学参数经统计学分析处理，皆无显著性差异（Ｐ＞０．０５）。In 16 Healthy male volunteers, 8 Mongolians and 8 Hans,each was given a single oral dose of 2 g tinidazole respectively. The course in vivo was compared by determining drug concentrations in plasma with HPLC method. The result showed that main pharmacokinetic parameters in Mongolian and Han were T1/2(Ka): 0.860.50 h and 1.220.12 h; T1/2(Ke):14.734.33 h and 13.041.44 h; Tpeak: 3.351.81 h and 4.121.54 h; Cmax:38.897.80 mgL-1 and 37.583.97 mgL-1; V/F :43.103.90 L and 45.608.40 L, respectively . The pharmacokinetic parameters obtained from our study showed no significant difference between the two groups (P>0.05).

关 键 词：替硝唑 药代动力学 高效液相色谱法 

分 类 号：R978.61[医药卫生—药品] R969.1[医药卫生—药学]