慢性肾功能不全对大鼠耳蜗影响的实验研究  

The influences of chronic renal failure on the cochlea: a experimental study

作　　者：叶丹[1,2] 孙爱华[1,2] 吴志英[1,2] 张天 

机构地区：[1]上海中医药大学岳阳医院肾内科 [2]第二军医大学长海医院耳鼻喉科

出　　处：《上海医学》1999年第5期289-291,共3页Shanghai Medical Journal

摘　　要：目的研究慢性肾功能不全（ＣＲＦ）对耳蜗的影响。方法应用５／６肾切除法制造大鼠ＣＲＦ模型，检测其肾功能及肾脏组织形态变化，观察ＣＲＦ对实验动物脑干听觉诱发电位（ＡＢＲ）阈及耳蜗螺旋器表面超微结构的影响。结果模型组ＡＢＲ阈提高值明显低于对照组（Ｐ＜０．０１），对螺旋器表面超微结构的损伤，主要表现为耳蜗各回内毛细胞静纤毛的不同程度缺失，外毛细胞静纤毛较少受损。结论ＣＲＦ可影响耳蜗听毛细胞的结构与功能，导致不同程度感音神经性聋。Objective To study the influences of CRF on ABR and the surface ultrastructure of the cochlea in experimentally induced chronic renal failure (CRF) in rats. Results are found as follows: The values of auditory threshold elevation and ABR in the CRF rats were significantly higher than those of the controls ( P <0.01). The changes in surface ultrastructure of cochlear in the CRF rats turned out to be varying degrees of loss of stereocilia of the inner hair cells in all the cochlear rows, and the stereocilia of outer hair cells were almost spared. Conclusions CRF can injure the the stereocilia of hair cells and result in various degrees of sensorineural hearing loss.

关 键 词：慢性 肾功能不全 脑干 听觉诱发电位 耳蜗 

分 类 号：R764.350.2[医药卫生—耳鼻咽喉科] R692.5[医药卫生—临床医学]