皮下注射肾上腺素复制气滞血瘀模型的血流动力学初探  

Brief exploring of hemodynamics in model with Qi stagnation and blood stasis induced by subcutaneous injection of epinephrine

作　　者：章正祥[1,2] 曹克刚[3] 王芬[4] 高永红[5] 范吉平[6] 

机构地区：[1]浙江中医药大学附属第一医院 [2]浙江省中医院神经内科,杭州310006 [3]北京中医药大学东直门医院,北京100700 [4]北京中医药大学第三附属医院,北京100029 [5]北京中医药大学东直门医院教育部重点实验室,北京100700 [6]中国中医科学院,北京100700

出　　处：《天津中医药》2011年第1期9-11,共3页Tianjin Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(30600828)

摘　　要：[目的]探讨皮下注射肾上腺素所致气滞血瘀模型的血流动力学变化。[方法]将24只大鼠分成肾上腺素组、生理盐水组、正常组,对各组大鼠连续2 h监测血流速度、心率、平均动脉压等血流动力学变化。[结果]皮下注射肾上腺素后,大鼠颈总动脉(CCA)血流速度下降(P<0.05),心率随时间无明显变化(P>0.05),CCA120 min平均动脉压较40 min降低(P<0.05)。肾上腺素组血流速度在60、80、100、120 min等时间点较正常组或生理盐水组均降低(P<0.05)。肾上腺素组心率较生理盐水组在60、80、100 min等时间点有所加快(P<0.05)。生理盐水组和肾上腺素组平均动脉压在0 min较正常组降低(P<0.05)。[结论]血流速度可作为肾上腺素所致气滞血瘀模型的量化评价指标,皮下注射肾上腺素后1 h是运用该模型进行活血化瘀药筛选与评价的较佳时间。[Objective] To investigate the hemodynamic changes of Qi stagnation and blood stasis caused by adrenaline injected subcutaneously.[Methods] Twenty-four rats were randomly divided into epinephrine group,normal saline group,normal group.All the rats were continuously monitoring hemodynamic changes of blood flow velocity,heart rate,mean arterial blood pressure for 2 h.[Results] After subcutaneously injection of adrenaline,blood flow velocity of rat common carotid artery（CCA） decreased（P0.05）;heart rate was not significant different with time changing（P0.05）;CCA mean arterial pressure at 120 min was lower than at 40 min（P0.05）.The blood flow in epinephrine group at 60 min,80 min,100 min,120 min was lower than the normal group or the normal saline group（P0.05）.The heart rate in epinephrine group was higher than that of normal saline group at 60 min,80 min and 100 min（P0.05）.CCA mean arterial pressure at 0 min in normal saline group and epinephrine group were lower than normal group（P0.05）.[Conclusion] Blood flow velocity can be used as one of the quantitative evaluation indicators of Qi stagnation and blood stasis caused by adrenaline,One hour after adrenaline injection was a apposite time for screening and evaluating the drug effect of blood-activating and stasis-dissolving with this model.

关 键 词：肾上腺素 气滞血瘀 模型 血流动力学 

分 类 号：R285.5[医药卫生—中药学]