国产PVPP用作片剂崩解剂的初步评价  

Preliminary estimation of domestic PVPP as a tablet disintegrant

作　　者：郭圣荣[1] 

机构地区：[1]上海医科大学药剂学教研室

出　　处：《中国药学杂志》1999年第6期384-386,共3页Chinese Pharmaceutical Journal

摘　　要：目的：对国产交联聚维酮（ＰＶＰＰ）用作片剂崩解剂初步评价。方法：参照美国药典中交聚集维酮（ｃｒｏｓｐｏｖｉｄｏｎｅ）的有关规格，评估ＰＶＰＰ的质量；测定国产ＰＶＰＰ的松密度、流动性、溶胀性、崩解性并与德国产的ＫｏｌｉｎｄｏｎＣＬ比较。结果：国产ＰＶＰＰ基本符合美国药典有关规定，具有和ＫｏｌｉｎｄｏｎＣＬ相似的性能。结论：国产ＰＶＰＰ可用作片剂崩解剂。OBJECTIVE: To estimate domestic PVPP as a tablet disintegrant. METHODS: To evaluate the quality of domestic PVPP by reference to the specifications of crospovidone in USP,and to study the bulk dinsity,fluidity,swelling and the effects of them on disintegrantion of tablets and compare with Kokkindon CL. RESULTS: Domestic PVPP basically conformed to the specifications in USP,its swelling and disintegrating properties were to Kollindon CL. CONCLUSION :The domestic PVPP can be used as one of tablet disintegrants.

关 键 词：崩解剂 溶胀性 交联聚维酮 PVPP 

分 类 号：TQ460.4[化学工程—制药化工]